DEFB118 (defensin beta 118) - Rat Genome Database

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Gene: DEFB118 (defensin beta 118) Canis lupus familiaris
Analyze
Symbol: DEFB118
Name: defensin beta 118
RGD ID: 12436651
Description: ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); membrane destabilizing activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-defensin 118; CBD118
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,894,219 - 20,900,503 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,893,663 - 20,900,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,542,462 - 20,548,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,581,391 - 21,587,689 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,581,268 - 21,587,804 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,859,714 - 20,866,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,964,652 - 20,970,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,395,297 - 21,401,413 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16033865   PMID:22301074  


Genomics

Comparative Map Data
DEFB118
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,894,219 - 20,900,503 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,893,663 - 20,900,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,542,462 - 20,548,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,581,391 - 21,587,689 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,581,268 - 21,587,804 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,859,714 - 20,866,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,964,652 - 20,970,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,395,297 - 21,401,413 (+)NCBIUU_Cfam_GSD_1.0
DEFB118
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,368,601 - 31,373,923 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,368,601 - 31,373,923 (+)EnsemblGRCh38hg38GRCh38
GRCh372029,956,404 - 29,961,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,420,089 - 29,424,825 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,420,088 - 29,424,825NCBI
Celera2026,712,675 - 26,717,411 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2026,745,178 - 26,750,482 (+)NCBIHuRef
CHM1_12029,860,364 - 29,865,668 (+)NCBICHM1_1
T2T-CHM13v2.02033,092,784 - 33,098,107 (+)NCBIT2T-CHM13v2.0
Defb21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,414,663 - 152,416,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,414,664 - 152,416,864 (+)EnsemblGRCm39 Ensembl
GRCm382152,572,743 - 152,574,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,572,744 - 152,574,944 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,398,480 - 152,400,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,264,185 - 152,266,384 (+)NCBIMGSCv36mm8
Celera2158,385,696 - 158,387,895 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.31NCBI
Defb21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,503,090 - 161,504,507 (+)NCBIGRCr8
mRatBN7.23141,042,810 - 141,044,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,042,810 - 141,044,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,947,797 - 144,949,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,531,633 - 153,532,947 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,271,990 - 151,273,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,047,638 - 148,048,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,047,638 - 148,048,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,453,217 - 154,455,520 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,910,151 - 142,911,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3139,793,810 - 139,795,124 (+)NCBICelera
Cytogenetic Map3q41NCBI
Defb118
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542229,554,310 - 29,560,660 (-)NCBIChiLan1.0ChiLan1.0
DEFB118
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,063,232 - 37,070,346 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,056,329 - 37,063,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,659,911 - 27,666,555 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12028,296,644 - 28,301,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,296,644 - 28,301,392 (+)Ensemblpanpan1.1panPan2
LOC100621695
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11735,167,885 - 35,173,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,889,039 - 39,895,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DEFB118
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1235,788,326 - 35,794,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl235,788,670 - 35,794,043 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605091,163,769 - 91,169,577 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DEFB118
74 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endoderm
integumental system
mesenchyme
reproductive system
respiratory system
1 3 4 3 1 5 4

Sequence


Ensembl Acc Id: ENSCAFT00000038821   ⟹   ENSCAFP00000034588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2420,893,663 - 20,900,618 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031532   ⟹   ENSCAFP00845024687
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2421,581,268 - 21,587,804 (+)Ensembl
RefSeq Acc Id: NM_001284489   ⟹   NP_001271418
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12420,894,219 - 20,900,503 (+)NCBI
Dog10K_Boxer_Tasha2420,542,462 - 20,548,755 (+)NCBI
ROS_Cfam_1.02421,581,391 - 21,587,689 (+)NCBI
UMICH_Zoey_3.12420,859,714 - 20,866,012 (+)NCBI
UNSW_CanFamBas_1.02420,964,652 - 20,970,934 (+)NCBI
UU_Cfam_GSD_1.02421,395,297 - 21,401,413 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001271418 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY59724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000034588.4
  ENSCAFP00845024687
  ENSCAFP00845024687.1
RefSeq Acc Id: NP_001271418   ⟸   NM_001284489
- Peptide Label: precursor
- UniProtKB: Q30KT6 (UniProtKB/TrEMBL),   A0A8C0JU58 (UniProtKB/TrEMBL),   A0A8P0NMN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000034588   ⟸   ENSCAFT00000038821
Ensembl Acc Id: ENSCAFP00845024687   ⟸   ENSCAFT00845031532
Protein Domains
Beta-defensin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025054 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845017813 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000038821.4 UniProtKB/TrEMBL
  ENSCAFT00845031532 ENTREZGENE
  ENSCAFT00845031532.1 UniProtKB/TrEMBL
Gene3D-CATH Antimicrobial Peptide, Beta-defensin 2, Chain A UniProtKB/TrEMBL
InterPro Beta-defensin UniProtKB/TrEMBL
  Beta_defensin UniProtKB/TrEMBL
KEGG Report cfa:100683741 UniProtKB/TrEMBL
NCBI Gene DEFB118 ENTREZGENE
PANTHER BETA-DEFENSIN 118 UniProtKB/TrEMBL
  BETA-DEFENSIN 123-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta_2 UniProtKB/TrEMBL
UniProt A0A8C0JU58 ENTREZGENE
  A0A8P0NMN4 ENTREZGENE, UniProtKB/TrEMBL
  Q30KT6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:97187 ENTREZGENE