S1PR4 (sphingosine-1-phosphate receptor 4)

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Gene: S1PR4 (sphingosine-1-phosphate receptor 4) Canis lupus familiaris

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Symbol:

S1PR4

Name:

sphingosine-1-phosphate receptor 4

RGD ID:

12429215

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); sphingosine-1-phosphate receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Neurodevelopmental Disorders (ortholog); RASopathy (ortholog); FOUND IN presynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

EDG6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6; sphingosine 1-phosphate receptor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,108,967 - 56,110,281 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,109,058 - 56,110,209 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,832,774 - 55,834,110 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,767,353 - 56,768,955 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,767,763 - 56,768,914 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,823,018 - 55,824,354 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,307,095 - 56,308,431 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,505,855 - 56,507,191 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (ISO)

Neurodevelopmental Disorders (ISO)

RASopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

sphingosine-1-phosphate receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

mitochondrion (IEA)

plasma membrane (IEA)

presynapse (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

protein binding (ISO)

sphingosine-1-phosphate receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

sphingosine 1-phosphate signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

S1PR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,108,967 - 56,110,281 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,109,058 - 56,110,209 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,832,774 - 55,834,110 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,767,353 - 56,768,955 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,767,763 - 56,768,914 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,823,018 - 55,824,354 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,307,095 - 56,308,431 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,505,855 - 56,507,191 (-)	NCBI		UU_Cfam_GSD_1.0

S1PR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	3,178,769 - 3,180,332 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	3,172,346 - 3,180,332 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	3,178,767 - 3,180,330 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,129,766 - 3,131,330 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	3,129,769 - 3,131,329	NCBI
Celera	19	3,115,117 - 3,116,711 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,945,831 - 2,947,425 (+)	NCBI		HuRef
CHM1_1	19	3,177,385 - 3,178,979 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	3,153,597 - 3,155,160 (+)	NCBI		T2T-CHM13v2.0

S1pr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,333,579 - 81,335,971 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	81,333,581 - 81,335,966 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	81,497,745 - 81,500,137 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,497,747 - 81,500,132 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,960,490 - 80,962,882 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,901,607 - 80,903,266 (-)	NCBI		MGSCv36	mm8
Celera	10	82,521,128 - 82,523,520 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

S1pr4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	8,858,528 - 8,860,804 (+)	NCBI		GRCr8
mRatBN7.2	7	8,207,767 - 8,210,043 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,208,098 - 8,211,893 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,093,800 - 11,096,076 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	12,969,283 - 12,971,559 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	10,836,403 - 10,838,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,077,411 - 11,079,687 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,077,411 - 11,079,687 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,244,600 - 11,246,876 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	9,691,709 - 9,693,985 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	9,692,102 - 9,693,986 (+)	NCBI
Celera	7	6,398,295 - 6,400,571 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

S1pr4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,244,696 - 5,245,862 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	5,243,797 - 5,247,649 (-)	NCBI	ChiLan1.0	ChiLan1.0

S1PR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	7,574,296 - 7,580,347 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	6,807,547 - 6,813,592 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	2,204,305 - 2,206,243 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,158,932 - 3,160,526 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

S1pr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,011,722 - 216,013,083 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,821,721 - 1,822,872 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,821,654 - 1,822,872 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

S1PR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,394,740 - 75,398,169 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	75,394,737 - 75,399,914 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,913,339 - 75,917,098 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

S1PR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,941,446 - 2,943,452 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	2,941,901 - 2,943,055 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	5,637,197 - 5,640,577 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

S1pr4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	6,039,778 - 6,040,941 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	6,038,527 - 6,041,024 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in S1PR4
8 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	4	21	22	16	6	6	6	6	29	18	10	8	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038429179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038504717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038567852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038631977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_849809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000030604 ⟹ ENSCAFP00000028441

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	56,109,058 - 56,110,209 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845018248 ⟹ ENSCAFP00845014234

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	56,767,763 - 56,768,914 (-)	Ensembl

RefSeq Acc Id:

XM_038429179 ⟹ XP_038285107

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	56,767,353 - 56,768,955 (-)	NCBI

RefSeq Acc Id:

XM_038504717 ⟹ XP_038360645

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	55,823,018 - 55,824,354 (-)	NCBI

RefSeq Acc Id:

XM_038567852 ⟹ XP_038423780

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	56,505,855 - 56,507,191 (-)	NCBI

RefSeq Acc Id:

XM_038631977 ⟹ XP_038487905

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	56,307,095 - 56,308,431 (-)	NCBI

RefSeq Acc Id:

XM_849809 ⟹ XP_854902

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	56,108,967 - 56,110,281 (-)	NCBI
Dog10K_Boxer_Tasha	20	55,832,774 - 55,834,110 (-)	NCBI

Sequence:

show sequence

GCCGGCCGGCGGGCGGCTCCACCCTGCCCCGGGCGAGCCACCCCGGGCCTCAGTCTGCCCCAGG
GGACCGCCATGAACGGCACGGGGCCCCCGGCGGCGGCCCCCGAGTCCTGCCAGCAGCTGGCGGC
CAGCGGGCACAGCCGCCTCATCGTGCTGCACTACAACCACTCGGGCCGGCTGGCGGGGCGCGCC
GGGCCCGACGAGGGGAGCCTGGGGGTGCTGCGCGGCGTCTTCGTGGCCGCCAGCTGCCTGGTGG
TGCTGGAGAACCTGCTGGTGCTGGTGGCCATCGCGACCCGCATGCGCTCGCGGCGCTGGGTGTA
CTACTGCCTGGTCAACATCACGCTGAGCGACCTGCTCACCGGCGTGGCCTACCTGGCCAACGTG
CTGCTGTCGGGCGCGCGCACCTTCCACCTGGCGCCCGCCCAGTGGTTCCTGCGCGAGGGCCTGC
TCTTCATGGCGCTGGCCGCCTCCACCTTCAGCCTGCTCTTCACCGCCGGCGAGCGCTTCGCCAC
CATGGTGCGGCCGGTGGCCGAGAGCGGGGCGAGCAAGCGCGGCCGGGTGTACGGCTTCATCGGG
CTGTGCTGGCTGCTGGCGGCGCTGCTGGGCCTGCTGCCGCTGCTCGGCTGGAACTGCGTGTGCG
CCTTCCCGCGCTGCTCCAGCCTGCTGCCGCTCTACTCCAAGGCCTACATCCTCTTCTGCGTGGG
GGTCTTCGCCTGCATCCTGGCCGCCATCATGGCGCTCTACGGGGCCATCTTCCGCGTGGTGCGC
GCCAACGGCCAGAAGGCCCCCCGGGCCCCCGCCCGCCGCAAGGCCCGCCGGCTGCTCAAGACGG
TGCTCATGATCCTGCTGGCCTTCGTCGTGTGCTGGGGCCCGCTCTTCGGCCTGCTGCTGGCCGA
CGTGTTCAGCTCCACGGACTGGGCGCAGGAGTACCTGCGCGGCATGGACTGGATCCTGGCGCTG
GCCGTGCTCAACTCGGCCGTGAACCCCCTCATCTACTCCTTCCGCAGCCGCGAGGTGTGCCAGG
CCGTGCTGGGCTTCCTCTGCTGCGGGTGTCTGCGGCTGGGGCTGCGGGGGCCCCGGGACTGCCT
GGCCCAGGTCACCGAGGCCCAGTCCTCCACCACGGACAGCTCGCTGAGGCCGAGGGACAGCTTT
CGGGGCTCCCGGTCGCTCAGCTTCCGGATGCGAGAGCCCCTGACCAGCATCTCCAGCGTGCGGA
GCGTCTGAGCCACTGCGGGGGCCGACCCGGCTGTCCTGTCCCCCCTCGCCCCCCGCCGTGCAGG
CCTCGGGCCGCGGGAGCCGGGAGCGCGCGGGGAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_038285107	(Get FASTA)	NCBI Sequence Viewer
	XP_038360645	(Get FASTA)	NCBI Sequence Viewer
	XP_038423780	(Get FASTA)	NCBI Sequence Viewer
	XP_038487905	(Get FASTA)	NCBI Sequence Viewer
	XP_854902	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000028441.4
	ENSCAFP00030011973.1
	ENSCAFP00040014498.1
	ENSCAFP00845014234
	ENSCAFP00845014234.1

RefSeq Acc Id:

XP_854902 ⟸ XM_849809

- UniProtKB:

A0A8C0REW1 (UniProtKB/TrEMBL), A0A8I3NR19 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGTGPPAAAPESCQQLAASGHSRLIVLHYNHSGRLAGRAGPDEGSLGVLRGVFVAASCLVVLE
NLLVLVAIATRMRSRRWVYYCLVNITLSDLLTGVAYLANVLLSGARTFHLAPAQWFLREGLLFM
ALAASTFSLLFTAGERFATMVRPVAESGASKRGRVYGFIGLCWLLAALLGLLPLLGWNCVCAFP
RCSSLLPLYSKAYILFCVGVFACILAAIMALYGAIFRVVRANGQKAPRAPARRKARRLLKTVLM
ILLAFVVCWGPLFGLLLADVFSSTDWAQEYLRGMDWILALAVLNSAVNPLIYSFRSREVCQAVL
GFLCCGCLRLGLRGPRDCLAQVTEAQSSTTDSSLRPRDSFRGSRSLSFRMREPLTSISSVRSV

hide sequence

Ensembl Acc Id:

ENSCAFP00000028441 ⟸ ENSCAFT00000030604

RefSeq Acc Id:

XP_038360645 ⟸ XM_038504717

RefSeq Acc Id:

XP_038487905 ⟸ XM_038631977

RefSeq Acc Id:	XP_038285107 ⟸ XM_038429179
- UniProtKB:	A0A8C0REW1 (UniProtKB/TrEMBL), A0A8I3NR19 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038423780 ⟸ XM_038567852
- UniProtKB:	A0A8C0REW1 (UniProtKB/TrEMBL), A0A8I3NR19 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845014234 ⟸ ENSCAFT00845018248

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000019278	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030007504	UniProtKB/TrEMBL
	ENSCAFG00040009015	UniProtKB/TrEMBL
	ENSCAFG00845010367	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000030604.5	UniProtKB/TrEMBL
	ENSCAFT00030013723.1	UniProtKB/TrEMBL
	ENSCAFT00040016728.1	UniProtKB/TrEMBL
	ENSCAFT00845018248	ENTREZGENE
	ENSCAFT00845018248.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	EDG6_rcpt	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	S1P_rcpt	UniProtKB/TrEMBL
KEGG Report	cfa:612082	UniProtKB/TrEMBL
NCBI Gene	S1PR4	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	PTHR22750:SF13	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	EDG6RECEPTOR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	S1PRECEPTOR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8C0REW1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NR19	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:110551	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)