ARHGEF17 (Rho guanine nucleotide exchange factor 17) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ARHGEF17 (Rho guanine nucleotide exchange factor 17) Canis lupus familiaris
Analyze
Symbol: ARHGEF17
Name: Rho guanine nucleotide exchange factor 17
RGD ID: 12330912
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rho guanine nucleotide exchange factor (GEF) 17
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,859,789 - 24,919,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,862,295 - 24,919,667 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,624,255 - 24,684,026 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,066,371 - 25,126,293 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,067,480 - 25,126,278 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,860,084 - 24,919,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,061,078 - 25,120,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,976,292 - 25,036,151 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARHGEF17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,859,789 - 24,919,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,862,295 - 24,919,667 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,624,255 - 24,684,026 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,066,371 - 25,126,293 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,067,480 - 25,126,278 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,860,084 - 24,919,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,061,078 - 25,120,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,976,292 - 25,036,151 (-)NCBIUU_Cfam_GSD_1.0
ARHGEF17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,308,276 - 73,369,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,308,276 - 73,369,388 (+)EnsemblGRCh38hg38GRCh38
GRCh371173,019,321 - 73,080,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,697,317 - 72,757,784 (+)NCBINCBI36Build 36hg18NCBI36
Build 341172,697,316 - 72,757,783NCBI
Celera1170,324,908 - 70,385,824 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,314,967 - 69,375,701 (+)NCBIHuRef
CHM1_11172,903,220 - 72,964,018 (+)NCBICHM1_1
T2T-CHM13v2.01173,237,439 - 73,298,525 (+)NCBIT2T-CHM13v2.0
Arhgef17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,518,953 - 100,581,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,518,959 - 100,581,314 (-)EnsemblGRCm39 Ensembl
GRCm387100,869,746 - 100,932,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,869,752 - 100,932,107 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,018,260 - 108,080,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,743,833 - 100,806,248 (-)NCBIMGSCv36mm8
Celera7101,220,490 - 101,283,194 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.45NCBI
Arhgef17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,642,690 - 164,702,241 (-)NCBIGRCr8
mRatBN7.21155,230,607 - 155,290,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,233,168 - 155,290,498 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,216,030 - 163,275,609 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,396,134 - 170,455,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,280,195 - 163,339,916 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0 Ensembl1165,911,718 - 165,967,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,105,535 - 172,164,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,316,868 - 158,375,737 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,399,688 - 158,454,770 (-)NCBI
Celera1153,312,407 - 153,371,361 (-)NCBICelera
Cytogenetic Map1q32NCBI
Arhgef17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,102,291 - 18,172,477 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,100,907 - 18,172,905 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,251,180 - 74,314,441 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,297,877 - 75,358,500 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,386,143 - 68,445,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11171,605,498 - 71,667,001 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,605,832 - 71,665,476 (+)Ensemblpanpan1.1panPan2
Arhgef17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,912,463 - 60,970,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,511,986 - 2,571,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,511,516 - 2,570,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.197,766,701 - 7,826,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,475,616 - 8,490,736 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,553,134 - 64,613,573 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,552,842 - 64,616,112 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,272,624 - 61,333,644 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,579,841 - 3,640,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,582,665 - 3,641,258 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGEF17
497 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000009046   ⟹   ENSCAFP00000008390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2124,862,295 - 24,919,667 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000047227   ⟹   ENSCAFP00000042807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2124,862,295 - 24,885,283 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845014901   ⟹   ENSCAFP00845011551
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2125,067,480 - 25,091,324 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845014973   ⟹   ENSCAFP00845011610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2125,067,493 - 25,126,278 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845015227   ⟹   ENSCAFP00845011823
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2125,067,493 - 25,126,278 (-)Ensembl
RefSeq Acc Id: XM_005633536   ⟹   XP_005633593
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12124,859,789 - 24,919,733 (-)NCBI
Dog10K_Boxer_Tasha2124,624,255 - 24,684,026 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038430176   ⟹   XP_038286104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02125,066,371 - 25,126,293 (-)NCBI
RefSeq Acc Id: XM_038505537   ⟹   XP_038361465
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12124,860,084 - 24,919,836 (-)NCBI
RefSeq Acc Id: XM_038568710   ⟹   XP_038424638
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02124,976,292 - 25,036,151 (-)NCBI
RefSeq Acc Id: XM_038632883   ⟹   XP_038488811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02125,061,078 - 25,120,836 (-)NCBI
RefSeq Acc Id: XP_005633593   ⟸   XM_005633536
- UniProtKB: A0A8P0N887 (UniProtKB/TrEMBL),   A0A8C0STK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000008390   ⟸   ENSCAFT00000009046
Ensembl Acc Id: ENSCAFP00000042807   ⟸   ENSCAFT00000047227
RefSeq Acc Id: XP_038361465   ⟸   XM_038505537
RefSeq Acc Id: XP_038488811   ⟸   XM_038632883
RefSeq Acc Id: XP_038286104   ⟸   XM_038430176
- UniProtKB: A0A8I3RUM1 (UniProtKB/TrEMBL),   A0A8C0STK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424638   ⟸   XM_038568710
- UniProtKB: A0A8C0STK5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845011551   ⟸   ENSCAFT00845014901
Ensembl Acc Id: ENSCAFP00845011823   ⟸   ENSCAFT00845015227
Ensembl Acc Id: ENSCAFP00845011610   ⟸   ENSCAFT00845014973
Protein Domains
DH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005619 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013601 UniProtKB/TrEMBL
  ENSCAFG00040016253 UniProtKB/TrEMBL
  ENSCAFG00845008396 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000009046.5 UniProtKB/TrEMBL
  ENSCAFT00000047227.4 UniProtKB/TrEMBL
  ENSCAFT00030025535.1 UniProtKB/TrEMBL
  ENSCAFT00040029936.1 UniProtKB/TrEMBL
  ENSCAFT00040030189.1 UniProtKB/TrEMBL
  ENSCAFT00845014901.1 UniProtKB/TrEMBL
  ENSCAFT00845014973 ENTREZGENE
  ENSCAFT00845014973.1 UniProtKB/TrEMBL
  ENSCAFT00845015227.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF10/ARHGEF17 UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene ARHGEF17 ENTREZGENE
PANTHER PTHR12877 UniProtKB/TrEMBL
  PTHR12877:SF15 UniProtKB/TrEMBL
Pfam PH_19 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  WD40_2 UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0N6T2_CANLF UniProtKB/TrEMBL
  A0A8C0STK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZY2_CANLF UniProtKB/TrEMBL
  A0A8I3N5U1_CANLF UniProtKB/TrEMBL
  A0A8I3RUM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N887 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38078 ENTREZGENE