LRFN4 (leucine rich repeat and fibronectin type III domain containing 4) - Rat Genome Database

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Gene: LRFN4 (leucine rich repeat and fibronectin type III domain containing 4) Canis lupus familiaris
Analyze
Symbol: LRFN4
Name: leucine rich repeat and fibronectin type III domain containing 4
RGD ID: 12313840
Description: INVOLVED IN regulation of postsynaptic density assembly (inferred); regulation of presynapse assembly (inferred); synaptic membrane adhesion (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); intellectual disability (ortholog); pyruvate carboxylase deficiency disease (ortholog); FOUND IN GABA-ergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat and fibronectin type-III domain-containing protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,495,971 - 50,499,062 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,495,971 - 50,499,068 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,105,908 - 49,109,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,446,247 - 51,449,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,446,247 - 51,448,995 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,630,687 - 50,633,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,210,034 - 50,213,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,999,800 - 51,003,086 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRFN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,495,971 - 50,499,062 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,495,971 - 50,499,068 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,105,908 - 49,109,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,446,247 - 51,449,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,446,247 - 51,448,995 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,630,687 - 50,633,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,210,034 - 50,213,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,999,800 - 51,003,086 (-)NCBIUU_Cfam_GSD_1.0
LRFN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,857,064 - 66,860,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,856,647 - 66,860,475 (+)EnsemblGRCh38hg38GRCh38
GRCh371166,624,535 - 66,627,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,381,549 - 66,384,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 341166,381,548 - 66,384,521NCBI
Celera1163,953,000 - 63,956,070 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,952,723 - 62,955,793 (+)NCBIHuRef
CHM1_11166,508,475 - 66,511,545 (+)NCBICHM1_1
T2T-CHM13v2.01166,853,340 - 66,856,751 (+)NCBIT2T-CHM13v2.0
Lrfn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,661,817 - 4,665,720 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,661,813 - 4,665,695 (-)EnsemblGRCm39 Ensembl
GRCm38194,611,784 - 4,615,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,611,785 - 4,615,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,611,784 - 4,615,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,611,792 - 4,615,502 (-)NCBIMGSCv36mm8
Celera194,482,803 - 4,486,850 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
Lrfn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,317,980 - 211,321,272 (-)NCBIGRCr8
mRatBN7.21201,888,569 - 201,891,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,888,569 - 201,891,861 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,241,488 - 210,244,780 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,333,987 - 217,337,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,025,007 - 210,028,299 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,850,037 - 219,855,771 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,850,037 - 219,853,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,716,517 - 226,720,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,202,925 - 207,206,217 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1199,429,461 - 199,432,753 (-)NCBICelera
Cytogenetic Map1q43NCBI
Lrfn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,524,786 - 18,527,916 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,524,786 - 18,527,916 (-)NCBIChiLan1.0ChiLan1.0
LRFN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,082,239 - 68,086,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,124,902 - 69,128,942 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,214,340 - 62,217,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,536,427 - 65,539,629 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,536,427 - 65,539,629 (+)Ensemblpanpan1.1panPan2
Lrfn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,339,090 - 6,342,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,780,745 - 2,784,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,781,439 - 2,784,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRFN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,576,622 - 5,580,009 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,576,625 - 5,579,397 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LRFN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,406,502 - 7,409,707 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,402,779 - 7,409,959 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,694,187 - 104,698,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrfn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,589,631 - 19,593,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,589,631 - 19,593,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRFN4
22 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000018821   ⟹   ENSCAFP00000017440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1850,495,971 - 50,499,068 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000073089   ⟹   ENSCAFP00000053936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1850,495,971 - 50,499,068 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845021034   ⟹   ENSCAFP00845016535
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1851,446,247 - 51,448,995 (-)Ensembl
RefSeq Acc Id: XM_038424845   ⟹   XP_038280773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01851,446,247 - 51,449,353 (-)NCBI
RefSeq Acc Id: XM_038424846   ⟹   XP_038280774
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01851,446,247 - 51,449,534 (-)NCBI
RefSeq Acc Id: XM_038454515   ⟹   XP_038310443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1849,105,908 - 49,109,194 (-)NCBI
RefSeq Acc Id: XM_038501089   ⟹   XP_038357017
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11850,630,687 - 50,633,791 (-)NCBI
RefSeq Acc Id: XM_038501091   ⟹   XP_038357019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11850,630,687 - 50,633,971 (-)NCBI
RefSeq Acc Id: XM_038563788   ⟹   XP_038419716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,999,800 - 51,002,906 (-)NCBI
RefSeq Acc Id: XM_038563789   ⟹   XP_038419717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,999,800 - 51,003,086 (-)NCBI
RefSeq Acc Id: XM_038627906   ⟹   XP_038483834
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01850,210,034 - 50,213,140 (-)NCBI
RefSeq Acc Id: XM_038627908   ⟹   XP_038483836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01850,210,034 - 50,213,320 (-)NCBI
RefSeq Acc Id: XM_847121   ⟹   XP_852214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11850,495,971 - 50,499,062 (-)NCBI
Dog10K_Boxer_Tasha1849,105,908 - 49,109,014 (-)NCBI
Sequence:
RefSeq Acc Id: XP_852214   ⟸   XM_847121
- UniProtKB: A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL),   A0A8C0R670 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000017440   ⟸   ENSCAFT00000018821
Ensembl Acc Id: ENSCAFP00000053936   ⟸   ENSCAFT00000073089
RefSeq Acc Id: XP_038357019   ⟸   XM_038501091
RefSeq Acc Id: XP_038357017   ⟸   XM_038501089
RefSeq Acc Id: XP_038483836   ⟸   XM_038627908
RefSeq Acc Id: XP_038483834   ⟸   XM_038627906
RefSeq Acc Id: XP_038280774   ⟸   XM_038424846
- UniProtKB: A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL),   A0A8C0R670 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038280773   ⟸   XM_038424845
- UniProtKB: A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL),   A0A8C0R670 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310443   ⟸   XM_038454515
- UniProtKB: A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL),   A0A8C0R670 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419717   ⟸   XM_038563789
- UniProtKB: A0A8C0R670 (UniProtKB/TrEMBL),   A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419716   ⟸   XM_038563788
- UniProtKB: A0A8C0R670 (UniProtKB/TrEMBL),   A0A8C0SJ82 (UniProtKB/TrEMBL),   A0A8I3NEU9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845016535   ⟸   ENSCAFT00845021034
Protein Domains
Fibronectin type-III   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011851 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018888 UniProtKB/TrEMBL
  ENSCAFG00040013270 UniProtKB/TrEMBL
  ENSCAFG00845011852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018821.5 UniProtKB/TrEMBL
  ENSCAFT00030034728.1 UniProtKB/TrEMBL
  ENSCAFT00040024497.1 UniProtKB/TrEMBL
  ENSCAFT00845021034 ENTREZGENE
  ENSCAFT00845021034.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRFN UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene LRFN4 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A8C0R670 ENTREZGENE
  A0A8C0SJ82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NEU9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42763 ENTREZGENE