COX8A (cytochrome c oxidase subunit VIIIA (ubiquitous)) - Rat Genome Database

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Gene: COX8A (cytochrome c oxidase subunit VIIIA (ubiquitous)) Canis lupus familiaris
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Symbol: COX8A
Name: cytochrome c oxidase subunit VIIIA (ubiquitous)
RGD ID: 12286154
Description: ENCODES a protein that exhibits acyltransferase activity (inferred); histone H2A acetyltransferase activity (inferred); histone H4 acetyltransferase activity (inferred); INVOLVED IN chromatin remodeling (inferred); mitochondrial electron transport, cytochrome c to oxygen (inferred); oxidative phosphorylation (inferred); ASSOCIATED WITH high grade glioma (ortholog); intellectual disability (ortholog); leukocyte adhesion deficiency 3 (ortholog); FOUND IN mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cytochrome c oxidase polypeptide VIII-liver; Cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC100686781  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,048,902 - 53,050,528 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,048,902 - 53,050,528 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,655,315 - 51,656,941 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,093,917 - 54,095,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,093,917 - 54,121,285 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,196,302 - 53,197,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,771,973 - 52,773,599 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,556,126 - 53,557,753 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,048,902 - 53,050,528 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,048,902 - 53,050,528 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,655,315 - 51,656,941 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,093,917 - 54,095,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,093,917 - 54,121,285 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,196,302 - 53,197,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,771,973 - 52,773,599 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,556,126 - 53,557,753 (-)NCBIUU_Cfam_GSD_1.0
COX8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,974,620 - 63,976,543 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,974,620 - 63,976,543 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,742,092 - 63,744,015 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,498,655 - 63,500,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,498,654 - 63,500,590NCBI
Celera1161,068,864 - 61,070,800 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,070,789 - 60,072,725 (+)NCBIHuRef
CHM1_11163,625,410 - 63,627,346 (+)NCBICHM1_1
T2T-CHM13v2.01163,964,325 - 63,966,248 (+)NCBIT2T-CHM13v2.0
Cox8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,192,523 - 7,194,981 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,192,518 - 7,194,981 (-)EnsemblGRCm39 Ensembl
GRCm38197,215,158 - 7,217,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,215,153 - 7,217,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,289,648 - 7,292,106 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,282,202 - 7,284,660 (-)NCBIMGSCv36mm8
Celera196,992,206 - 6,994,664 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.28NCBI
Cox8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,831,302 - 213,833,623 (-)NCBIGRCr8
mRatBN7.21204,402,118 - 204,404,439 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1212,752,049 - 212,754,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,847,346 - 219,849,667 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,538,398 - 212,540,719 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,466,575 - 222,468,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,466,575 - 222,468,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,457,144 - 229,459,465 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,886,141 - 209,888,462 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,044,570 - 210,046,810 (-)NCBI
Celera1201,934,741 - 201,937,062 (-)NCBICelera
Cytogenetic Map1q43NCBI
LOC102024691
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,062,061 - 21,065,655 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542221,062,061 - 21,065,655 (-)NCBIChiLan1.0ChiLan1.0
LOC103783322
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,200,661 - 65,203,140 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,246,353 - 66,248,315 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,331,536 - 59,333,496 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,679,993 - 62,681,978 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,679,993 - 62,681,978 (+)Ensemblpanpan1.1panPan2
LOC101964414
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,729,911 - 8,732,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365995,172,260 - 5,175,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365995,172,260 - 5,175,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,101,613 - 8,103,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,101,609 - 8,103,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,218,517 - 7,220,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233475
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,269,020 - 10,271,484 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,269,021 - 10,271,175 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,605,899 - 107,608,131 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101706868
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,295,594 - 22,298,701 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,295,594 - 22,298,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX8A
14 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023403   ⟹   ENSCAFP00000021734
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1853,048,902 - 53,050,528 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054773   ⟹   ENSCAFP00845043083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,093,917 - 54,095,544 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054780   ⟹   ENSCAFP00845043089
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,093,918 - 54,121,143 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054785   ⟹   ENSCAFP00845043094
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,105,308 - 54,121,143 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054797   ⟹   ENSCAFP00845043105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,105,312 - 54,121,084 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054807   ⟹   ENSCAFP00845043113
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,105,314 - 54,121,285 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845054811   ⟹   ENSCAFP00845043116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1854,105,314 - 54,121,285 (-)Ensembl
RefSeq Acc Id: NM_001252370   ⟹   NP_001239299
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11853,048,902 - 53,050,528 (-)NCBI
Dog10K_Boxer_Tasha1851,655,315 - 51,656,941 (-)NCBI
ROS_Cfam_1.01854,093,917 - 54,095,544 (-)NCBI
UMICH_Zoey_3.11853,196,302 - 53,197,928 (-)NCBI
UNSW_CanFamBas_1.01852,771,973 - 52,773,599 (-)NCBI
UU_Cfam_GSD_1.01853,556,126 - 53,557,753 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001239299   ⟸   NM_001252370
- UniProtKB: A0A8C0SNZ0 (UniProtKB/TrEMBL),   A0A8C0KNH2 (UniProtKB/TrEMBL),   A0A8I3QBW6 (UniProtKB/TrEMBL),   A0A8C0PKN5 (UniProtKB/TrEMBL),   A0A8I3MTJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021734   ⟸   ENSCAFT00000023403
Ensembl Acc Id: ENSCAFP00845043116   ⟸   ENSCAFT00845054811
Ensembl Acc Id: ENSCAFP00845043089   ⟸   ENSCAFT00845054780
Ensembl Acc Id: ENSCAFP00845043094   ⟸   ENSCAFT00845054785
Ensembl Acc Id: ENSCAFP00845043083   ⟸   ENSCAFT00845054773
Ensembl Acc Id: ENSCAFP00845043105   ⟸   ENSCAFT00845054797
Ensembl Acc Id: ENSCAFP00845043113   ⟸   ENSCAFT00845054807

Promoters
RGD ID:13686630
Promoter ID:EPDNEW_C4700
Type:initiation region
Name:COX8A_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11853,050,495 - 53,050,555EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014738 Ensembl
  ENSCAFG00000014746 UniProtKB/TrEMBL
  ENSCAFG00000024399 UniProtKB/TrEMBL
  ENSCAFG00030009950 UniProtKB/TrEMBL
  ENSCAFG00040000386 UniProtKB/TrEMBL
  ENSCAFG00040015318 UniProtKB/TrEMBL
  ENSCAFG00845004814 UniProtKB/TrEMBL
  ENSCAFG00845030809 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023403.4 UniProtKB/TrEMBL
  ENSCAFT00000037684.4 UniProtKB/TrEMBL
  ENSCAFT00030018399.1 UniProtKB/TrEMBL
  ENSCAFT00040000639.1 UniProtKB/TrEMBL
  ENSCAFT00040028236.1 UniProtKB/TrEMBL
  ENSCAFT00845008621.1 UniProtKB/TrEMBL
  ENSCAFT00845054773 ENTREZGENE
  ENSCAFT00845054773.1 UniProtKB/TrEMBL
  ENSCAFT00845054785.1 UniProtKB/TrEMBL
  ENSCAFT00845054811.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
  4.10.81.10 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Cyt_c_oxidase_su8 UniProtKB/TrEMBL
  Cyt_c_oxidase_su8_sf UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  NAA40 UniProtKB/TrEMBL
KEGG Report cfa:476040 UniProtKB/TrEMBL
NCBI Gene COX8A ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 8A, MITOCHONDRIAL UniProtKB/TrEMBL
  N-ALPHA-ACETYLTRANSFERASE 40 UniProtKB/TrEMBL
  PTHR16717 UniProtKB/TrEMBL
  PTHR20531 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  COX8 UniProtKB/TrEMBL
PROSITE GNAT UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
  SSF81431 UniProtKB/TrEMBL
UniProt A0A8C0KNH2 ENTREZGENE
  A0A8C0PKN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SNZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MTJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q5L1_CANLF UniProtKB/TrEMBL
  A0A8I3QBW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S7V0_CANLF UniProtKB/TrEMBL
  COX8A_CANLF UniProtKB/Swiss-Prot, ENTREZGENE