CTSW (cathepsin W) - Rat Genome Database

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Gene: CTSW (cathepsin W) Canis lupus familiaris
Analyze
Symbol: CTSW
Name: cathepsin W
RGD ID: 12113335
Description: ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal recessive cutis laxa type IB (ortholog); Bardet-Biedl syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,381,999 - 51,386,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,382,122 - 51,386,261 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,990,509 - 49,994,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,420,076 - 52,424,413 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,420,078 - 52,424,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,520,148 - 51,524,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,094,514 - 51,098,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,883,832 - 51,888,169 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CTSW
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,381,999 - 51,386,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,382,122 - 51,386,261 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,990,509 - 49,994,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,420,076 - 52,424,413 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,420,078 - 52,424,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,520,148 - 51,524,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,094,514 - 51,098,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,883,832 - 51,888,169 (-)NCBIUU_Cfam_GSD_1.0
CTSW
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,879,837 - 65,883,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,879,809 - 65,883,741 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,647,308 - 65,651,212 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,403,860 - 65,407,788 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,403,859 - 65,407,786NCBI
Celera1162,971,189 - 62,975,117 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,973,801 - 61,977,729 (+)NCBIHuRef
CHM1_11165,531,698 - 65,535,626 (+)NCBICHM1_1
T2T-CHM13v2.01165,872,897 - 65,876,801 (+)NCBIT2T-CHM13v2.0
Ctsw
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,515,071 - 5,518,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,515,071 - 5,518,535 (-)EnsemblGRCm39 Ensembl
GRCm38195,465,043 - 5,468,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,465,043 - 5,468,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,465,240 - 5,468,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,465,242 - 5,468,498 (-)NCBIMGSCv36mm8
Celera195,337,212 - 5,340,470 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.33NCBI
Ctsw
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,201,904 - 212,208,028 (-)NCBIGRCr8
mRatBN7.21202,772,395 - 202,777,021 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,772,572 - 202,775,964 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,124,874 - 211,128,241 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,217,976 - 218,221,364 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,909,017 - 210,912,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,844,579 - 220,847,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,844,558 - 220,848,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,773,906 - 227,777,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,108,632 - 208,112,020 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,262,084 - 208,265,473 (-)NCBI
Celera1200,308,657 - 200,312,045 (-)NCBICelera
Cytogenetic Map1q43NCBI
Ctsw
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,440,394 - 19,443,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,439,997 - 19,443,451 (-)NCBIChiLan1.0ChiLan1.0
CTSW
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,105,761 - 67,112,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,146,773 - 68,155,119 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,239,862 - 61,244,034 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,569,587 - 64,573,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,569,587 - 64,573,534 (+)Ensemblpanpan1.1panPan2
Ctsw
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,214,993 - 7,220,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,657,453 - 3,660,922 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,657,255 - 3,661,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSW
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,446,105 - 6,450,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,550,132 - 5,554,381 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSW
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,374,426 - 8,378,496 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,369,620 - 8,378,578 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,663,607 - 105,667,735 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsw
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,533,487 - 20,538,436 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,533,448 - 20,537,706 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSW
49 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000020910   ⟹   ENSCAFP00000019414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1851,382,122 - 51,386,261 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000089802   ⟹   ENSCAFP00000062600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1851,382,241 - 51,386,261 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031243   ⟹   ENSCAFP00845024457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1852,420,078 - 52,424,365 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031351   ⟹   ENSCAFP00845024544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1852,420,318 - 52,424,365 (-)Ensembl
RefSeq Acc Id: XM_038424941   ⟹   XP_038280869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01852,420,076 - 52,424,413 (-)NCBI
RefSeq Acc Id: XM_038501180   ⟹   XP_038357108
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11851,520,148 - 51,524,481 (-)NCBI
RefSeq Acc Id: XM_038563881   ⟹   XP_038419809
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01851,883,832 - 51,888,169 (-)NCBI
RefSeq Acc Id: XM_038628007   ⟹   XP_038483935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01851,094,514 - 51,098,851 (-)NCBI
RefSeq Acc Id: XM_540846   ⟹   XP_540846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11851,381,999 - 51,386,277 (-)NCBI
Dog10K_Boxer_Tasha1849,990,509 - 49,994,844 (-)NCBI
Sequence:
RefSeq Acc Id: XP_540846   ⟸   XM_540846
- UniProtKB: A0A8C0KRE6 (UniProtKB/TrEMBL),   A0A8C0SR41 (UniProtKB/TrEMBL),   A0A8I3NT28 (UniProtKB/TrEMBL),   A0A8C0NHP6 (UniProtKB/TrEMBL),   A0A8I3NYE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000019414   ⟸   ENSCAFT00000020910
Ensembl Acc Id: ENSCAFP00000062600   ⟸   ENSCAFT00000089802
RefSeq Acc Id: XP_038357108   ⟸   XM_038501180
RefSeq Acc Id: XP_038483935   ⟸   XM_038628007
RefSeq Acc Id: XP_038280869   ⟸   XM_038424941
- UniProtKB: A0A8C0KRE6 (UniProtKB/TrEMBL),   A0A8C0SR41 (UniProtKB/TrEMBL),   A0A8I3NT28 (UniProtKB/TrEMBL),   A0A8C0NHP6 (UniProtKB/TrEMBL),   A0A8I3NYE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419809   ⟸   XM_038563881
- UniProtKB: A0A8C0KRE6 (UniProtKB/TrEMBL),   A0A8C0NHP6 (UniProtKB/TrEMBL),   A0A8C0SR41 (UniProtKB/TrEMBL),   A0A8I3NT28 (UniProtKB/TrEMBL),   A0A8I3NYE1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024544   ⟸   ENSCAFT00845031351
Ensembl Acc Id: ENSCAFP00845024457   ⟸   ENSCAFT00845031243
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Promoters
RGD ID:13686599
Promoter ID:EPDNEW_C4665
Type:single initiation site
Name:CTSW_1
Description:cathepsin W
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11851,386,278 - 51,386,338EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013168 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014636 UniProtKB/TrEMBL
  ENSCAFG00040015678 UniProtKB/TrEMBL
  ENSCAFG00845017646 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020910.5 UniProtKB/TrEMBL
  ENSCAFT00000089802.2 UniProtKB/TrEMBL
  ENSCAFT00030027110.1 UniProtKB/TrEMBL
  ENSCAFT00030027201.1 UniProtKB/TrEMBL
  ENSCAFT00040028908.1 UniProtKB/TrEMBL
  ENSCAFT00040028980.1 UniProtKB/TrEMBL
  ENSCAFT00845031243 ENTREZGENE
  ENSCAFT00845031243.1 UniProtKB/TrEMBL
  ENSCAFT00845031351.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report cfa:483725 UniProtKB/TrEMBL
NCBI Gene CTSW ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C0KRE6 ENTREZGENE
  A0A8C0NHP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SR41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NT28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NYE1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39716 ENTREZGENE