CTSW (cathepsin W) - Rat Genome Database

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Gene: CTSW (cathepsin W) Sus scrofa
Analyze
Symbol: CTSW
Name: cathepsin W
RGD ID: 13932901
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); proteolysis involved in protein catabolic process (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal recessive cutis laxa type IB (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN extracellular space (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,446,105 - 6,450,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,550,132 - 5,554,381 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA,IEA)
lysosome  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
CTSW
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,446,105 - 6,450,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,550,132 - 5,554,381 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSW
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,879,837 - 65,883,741 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,879,809 - 65,883,741 (+)EnsemblGRCh38hg38GRCh38
GRCh371165,647,308 - 65,651,212 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,403,860 - 65,407,788 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,403,859 - 65,407,786NCBI
Celera1162,971,189 - 62,975,117 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,973,801 - 61,977,729 (+)NCBIHuRef
CHM1_11165,531,698 - 65,535,626 (+)NCBICHM1_1
T2T-CHM13v2.01165,872,897 - 65,876,801 (+)NCBIT2T-CHM13v2.0
Ctsw
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,515,071 - 5,518,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,515,071 - 5,518,535 (-)EnsemblGRCm39 Ensembl
GRCm38195,465,043 - 5,468,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,465,043 - 5,468,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,465,240 - 5,468,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,465,242 - 5,468,498 (-)NCBIMGSCv36mm8
Celera195,337,212 - 5,340,470 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.33NCBI
Ctsw
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,201,904 - 212,208,028 (-)NCBIGRCr8
mRatBN7.21202,772,395 - 202,777,021 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,772,572 - 202,775,964 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,124,874 - 211,128,241 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,217,976 - 218,221,364 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,909,017 - 210,912,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,844,579 - 220,847,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,844,558 - 220,848,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,773,906 - 227,777,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,108,632 - 208,112,020 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,262,084 - 208,265,473 (-)NCBI
Celera1200,308,657 - 200,312,045 (-)NCBICelera
Cytogenetic Map1q43NCBI
Ctsw
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,440,394 - 19,443,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,439,997 - 19,443,451 (-)NCBIChiLan1.0ChiLan1.0
CTSW
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,105,761 - 67,112,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,146,773 - 68,155,119 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,239,862 - 61,244,034 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,569,587 - 64,573,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,569,587 - 64,573,534 (+)Ensemblpanpan1.1panPan2
CTSW
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,381,999 - 51,386,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,382,122 - 51,386,261 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,990,509 - 49,994,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,420,076 - 52,424,413 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,420,078 - 52,424,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,520,148 - 51,524,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,094,514 - 51,098,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,883,832 - 51,888,169 (-)NCBIUU_Cfam_GSD_1.0
Ctsw
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,214,993 - 7,220,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,657,453 - 3,660,922 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,657,255 - 3,661,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSW
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,374,426 - 8,378,496 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,369,620 - 8,378,578 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,663,607 - 105,667,735 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsw
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,533,487 - 20,538,436 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,533,448 - 20,537,706 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSW
87 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 4
Low 10 2 3 1 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014177   ⟹   ENSSSCP00000013791
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000060947   ⟹   ENSSSCP00000038678
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000101678   ⟹   ENSSSCP00000080792
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,446,105 - 6,450,360 (-)Ensembl
RefSeq Acc Id: XM_003122523   ⟹   XP_003122571
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.126,446,105 - 6,450,357 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082817   ⟹   XP_020938476
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.126,446,105 - 6,450,183 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003122571   ⟸   XM_003122523
- Peptide Label: isoform X1
- UniProtKB: F1RU23 (UniProtKB/TrEMBL),   A0A4X1UGM7 (UniProtKB/TrEMBL),   A0A8D1AYU2 (UniProtKB/TrEMBL),   A0A8D1IGI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938476   ⟸   XM_021082817
- Peptide Label: isoform X2
- UniProtKB: A0A8D1AYU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038678   ⟸   ENSSSCT00000060947
RefSeq Acc Id: ENSSSCP00000013791   ⟸   ENSSSCT00000014177
RefSeq Acc Id: ENSSSCP00000080792   ⟸   ENSSSCT00000101678
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005019132 UniProtKB/TrEMBL
  ENSSSCG00030019724 UniProtKB/TrEMBL
  ENSSSCG00035069939 UniProtKB/TrEMBL
  ENSSSCG00045024937 UniProtKB/TrEMBL
  ENSSSCG00050061159 UniProtKB/TrEMBL
  ENSSSCG00060071256 UniProtKB/TrEMBL
  ENSSSCG00065013316 UniProtKB/TrEMBL
  ENSSSCG00070017208 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014177 ENTREZGENE
  ENSSSCT00000014177.4 UniProtKB/TrEMBL
  ENSSSCT00000060947.3 UniProtKB/TrEMBL
  ENSSSCT00000101678.1 UniProtKB/TrEMBL
  ENSSSCT00005030398.1 UniProtKB/TrEMBL
  ENSSSCT00030027221.1 UniProtKB/TrEMBL
  ENSSSCT00035094494.1 UniProtKB/TrEMBL
  ENSSSCT00045042728.1 UniProtKB/TrEMBL
  ENSSSCT00050083351.1 UniProtKB/TrEMBL
  ENSSSCT00060097425.1 UniProtKB/TrEMBL
  ENSSSCT00065017717.1 UniProtKB/TrEMBL
  ENSSSCT00070033937.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report ssc:100525853 UniProtKB/TrEMBL
NCBI Gene CTSW ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
  PTHR12411:SF101 UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A287A4H5_PIG UniProtKB/TrEMBL
  A0A4X1UGM7 ENTREZGENE
  A0A8D1AYU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IGI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FNM5_PIG UniProtKB/TrEMBL
  F1RU23 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1UGM7 UniProtKB/TrEMBL
VGNC ID VGNC:87080 ENTREZGENE