SPZ1 (spermatogenic leucine zipper 1)

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Gene: SPZ1 (spermatogenic leucine zipper 1) Canis lupus familiaris

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Symbol:

SPZ1

Name:

spermatogenic leucine zipper 1

RGD ID:

12065053

Description:

ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); E-box binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

spermatogenic leucine zipper protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,749,673 - 26,751,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	26,750,004 - 26,751,107 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,990,405 - 27,992,113 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	26,669,103 - 26,670,811 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	26,669,434 - 26,670,656 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	26,609,257 - 26,610,964 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	26,581,463 - 26,583,171 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,864,269 - 26,865,977 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (IEA)

Cellular Component

nucleus (ISO)

Molecular Function

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (ISO)

E-box binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SPZ1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,749,673 - 26,751,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	26,750,004 - 26,751,107 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,990,405 - 27,992,113 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	26,669,103 - 26,670,811 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	26,669,434 - 26,670,656 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	26,609,257 - 26,610,964 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	26,581,463 - 26,583,171 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,864,269 - 26,865,977 (-)	NCBI		UU_Cfam_GSD_1.0

SPZ1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	80,320,002 - 80,321,842 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	80,319,625 - 80,321,842 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	79,615,821 - 79,617,661 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	79,651,599 - 79,653,417 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	75,517,111 - 75,518,982 (+)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	74,823,927 - 74,825,798 (+)	NCBI		HuRef
CHM1_1	5	79,048,913 - 79,050,784 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	80,803,970 - 80,805,810 (+)	NCBI		T2T-CHM13v2.0

Spz1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	92,711,139 - 92,712,740 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	92,711,144 - 92,712,680 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	92,574,631 - 92,576,232 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	92,574,636 - 92,576,172 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	93,344,586 - 93,346,187 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	93,675,389 - 93,676,925 (-)	NCBI		MGSCv36	mm8
Celera	13	96,189,283 - 96,190,884 (-)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.75	NCBI

Spz1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	25,531,797 - 25,533,393 (-)	NCBI		GRCr8
mRatBN7.2	2	23,796,741 - 23,798,337 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,796,742 - 23,798,337 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	30,826,913 - 30,828,506 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,927,260 - 28,928,853 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	23,755,439 - 23,757,032 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	22,145,457 - 22,147,053 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	22,145,404 - 22,147,115 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	41,348,984 - 41,350,580 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,809,373 - 22,810,969 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	19,886,565 - 19,888,161 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Spz1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955418	29,458,836 - 29,460,519 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPZ1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	34,986,141 - 34,988,592 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	33,139,245 - 33,142,218 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,995,430 - 34,997,935 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	35,269,307 - 35,270,912 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	35,269,377 - 35,270,670 (-)	Ensembl	panpan1.1		panPan2

Spz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	182,837,544 - 182,839,384 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936549	8,019,767 - 8,020,915 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPZ1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	89,014,413 - 89,016,061 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	89,014,196 - 89,016,839 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	90,882,105 - 90,883,844 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPZ1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	74,501,194 - 74,503,699 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	74,502,216 - 74,503,364 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	23,356,150 - 23,358,189 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spz1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624743	1,321,398 - 1,322,780 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SPZ1
15 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
2	2	4	4	4	2	1	2	2	6	4	2	9	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038471164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038532083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038596338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038660532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_546045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000014050 ⟹ ENSCAFP00000012997

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	3	26,750,004 - 26,751,107 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845010640 ⟹ ENSCAFP00845008293

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	3	26,669,434 - 26,670,656 (-)	Ensembl

RefSeq Acc Id:

XM_038471164 ⟹ XP_038327092

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	3	26,609,257 - 26,610,964 (-)	NCBI

RefSeq Acc Id:

XM_038532083 ⟹ XP_038388011

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	3	26,864,269 - 26,865,977 (-)	NCBI

RefSeq Acc Id:

XM_038596338 ⟹ XP_038452266

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	3	26,581,463 - 26,583,171 (-)	NCBI

RefSeq Acc Id:

XM_038660532 ⟹ XP_038516460

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	3	26,669,103 - 26,670,811 (-)	NCBI

RefSeq Acc Id:

XM_546045 ⟹ XP_546045

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	3	26,749,673 - 26,751,387 (-)	NCBI
Dog10K_Boxer_Tasha	3	27,990,405 - 27,992,113 (-)	NCBI

Sequence:

show sequence

GTCAGGGAGTAGACACCAGAAGCTTGGAGAAGGACAGATGGAGCCCTAGCTCCTGGTCCCCTTT
CTCACCCTCCTTCCCCCCTAGGTCATCTGAAATGTCACCTTTCACCTAATCATCATCTCCTTGG
TTTCAGACCTTAACTCTGGTCTCTCGACTTCTGCTTAGTTCCACATTCTCTACCCTTTTGCAAA
GAGGACTACCACATTCTCTTCCTGGAGACTTTAAGGCTTTTCTGCTTGCCACATGCTCTAATCA
CCAGCCCCTCCTAACTCAGCTGAGATGGAAGTGTCCACCCTCTCCAAAACTCTTAAGCCAACTC
CCGGTCTCAATCAAGAGTCTTTGGGCCCTAGGATTATCCTTGCCTTATTTGAAATTGGATCACT
TCCTCCTGTCTCCTGGTGTTTTCTCCCTTCCCCAAACAATAGTGACCATCAAGTAGCTGAACAA
CAGACTGCACAGAAGTTTGAAAATCTCTTAAAAGATATTAAAGATATCATTAAAAATGTGACAA
GTAATGAAGAAAAGATCACAGAAGTCAAAGATTCTTTTGAGGAAATCAGTATTTCTGAGGATGT
GTCAGAACTTAAAGAAAAAATCAGAGAACTTGATAAGATAAATGAAGTGTTATTGAACAACCTG
CTTGGTTGCTCAGACCTAGAGAAAGAAGAGAATGCAAAAAAACAGATGATAGTGGAAAACCAGA
ACTGTAAGGACACGGTACAAGTCTTTAGAAGTGATTTGGTAAATTGTTCAGAAGAAAACAGAGC
CCTTGATGAAACTCAGTTAAGTAAGGAAAAAGCAAAATATAGACTCCCTCATGTTCAAGAAGAA
AATATCAAACTTAGGAACAACATGGAGCAGTTACTACAGGAAGCAGAACACTGGAATGTGCAAC
ATGCTGAGCTCAGTGAACTAATAAGAACATATCAGAAATCTCAGAAAGATATACAAGAAACTCT
TAAAAATAATGGAGCACATTTCCAAACTCAATCAAATGAGAAGGTGTCAGCTCAGCATGAACTG
GAGGAACAAGTGAAAAAACTGGAACATGACACATATTCATTGCATTTGATTTCAGCTTTGCTGG
AAAATGAATGTCAGATCTTACAGCAGAGAATAGAGCTTCTCAAGGAACTCCATCATCAGAAAGA
GGGAACTCTGCAAGAGAAGCCAATTCAGAAAAACGGTGAAAAGGACAAGAAAAAACAGAAGCTA
TCAGCAGAGCATAAGCCAAAAATGCAAGAAAAAGAGGGTACATTTCAGAAAAAAGACAAATTCT
ACAGAGGCCTGGATGCTGGTAGCAAGAAAGCGCTTAATAACCACTTCAATACTCATATTGCAAG
AGGAACTCCTGTGGAAAAATCATCCAGCAGCCTAACTTAGAAAATACCAAAAGTAGAAGAAAAG
GCAATTCTTCAAAAACTGTAACACATCAACTCTAGGCATAATCAATCATCAAACCTAGGATAGA
TCTGCTGGTTTGACAAGAGTAAACCATAGAACAAGAAGATTAACACTTAGATTGTTCATTACCT
CAGTAGTTATGTAAGTTTGGTGTTTCATGACCATTAGTGCCAGTATCAAGTTCATAACCTGTTG
TACAATTTGCTTGTTTTTTGTATTTATTAGAGATCCTATGACACTGTAACCAAGAGGGAGAAGT
TATAGGTCCAATTAATAAAGATCTAAATAAAAACTAGAATAAAAATGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038327092	(Get FASTA)	NCBI Sequence Viewer
	XP_038388011	(Get FASTA)	NCBI Sequence Viewer
	XP_038452266	(Get FASTA)	NCBI Sequence Viewer
	XP_038516460	(Get FASTA)	NCBI Sequence Viewer
	XP_546045	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000012997.4
	ENSCAFP00040006577.1
	ENSCAFP00845008293.1

RefSeq Acc Id:

XP_546045 ⟸ XM_546045

- UniProtKB:

A0A8C0QFP9 (UniProtKB/TrEMBL), A0A8I3MYI7 (UniProtKB/TrEMBL), A0A8P0SDV6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEVSTLSKTLKPTPGLNQESLGPRIILALFEIGSLPPVSWCFLPSPNNSDHQVAEQQTAQKFEN
LLKDIKDIIKNVTSNEEKITEVKDSFEEISISEDVSELKEKIRELDKINEVLLNNLLGCSDLEK
EENAKKQMIVENQNCKDTVQVFRSDLVNCSEENRALDETQLSKEKAKYRLPHVQEENIKLRNNM
EQLLQEAEHWNVQHAELSELIRTYQKSQKDIQETLKNNGAHFQTQSNEKVSAQHELEEQVKKLE
HDTYSLHLISALLENECQILQQRIELLKELHHQKEGTLQEKPIQKNGEKDKKKQKLSAEHKPKM
QEKEGTFQKKDKFYRGLDAGSKKALNNHFNTHIARGTPVEKSSSSLT

hide sequence

Ensembl Acc Id:

ENSCAFP00000012997 ⟸ ENSCAFT00000014050

RefSeq Acc Id:

XP_038327092 ⟸ XM_038471164

RefSeq Acc Id:

XP_038452266 ⟸ XM_038596338

RefSeq Acc Id:	XP_038516460 ⟸ XM_038660532
- UniProtKB:	A0A8C0QFP9 (UniProtKB/TrEMBL), A0A8I3MYI7 (UniProtKB/TrEMBL), A0A8P0SDV6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038388011 ⟸ XM_038532083
- UniProtKB:	A0A8C0QFP9 (UniProtKB/TrEMBL), A0A8I3MYI7 (UniProtKB/TrEMBL), A0A8P0SDV6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845008293 ⟸ ENSCAFT00845010640

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000008854	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040003961	UniProtKB/TrEMBL
	ENSCAFG00845006011	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000014050.4	UniProtKB/TrEMBL
	ENSCAFT00040007547.1	UniProtKB/TrEMBL
	ENSCAFT00845010640.1	UniProtKB/TrEMBL
InterPro	Spz1	UniProtKB/TrEMBL
KEGG Report	cfa:488928	UniProtKB/TrEMBL
NCBI Gene	SPZ1	ENTREZGENE
PANTHER	PTHR47889	UniProtKB/TrEMBL
	SPERMATOGENIC LEUCINE ZIPPER PROTEIN 1	UniProtKB/TrEMBL
UniProt	A0A8C0QFP9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MYI7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SDV6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:46785	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD