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Gene: NANS (N-acetylneuraminate synthase) Pan paniscus

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Symbol:

NANS

Name:

N-acetylneuraminate synthase

RGD ID:

12039541

Description:

ENCODES a protein that exhibits N-acylneuraminate-9-phosphate synthase activity (inferred); transferase activity, transferring alkyl or aryl (other than methyl) groups (inferred); INVOLVED IN carbohydrate biosynthetic process (inferred); CMP-N-acetylneuraminate biosynthetic process (inferred); glycosylation (inferred); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH bone development disease (ortholog); congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sialic acid synthase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	41,375,294 - 41,409,330 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	41,377,671 - 41,411,713 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	69,146,016 - 69,172,355 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	97,267,088 - 97,293,385 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	97,267,088 - 97,293,385 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bone development disease (ISO)

congenital disorder of glycosylation Ii (ISO)

congenital disorder of glycosylation type II (ISO)

congenital myasthenic syndrome 14 (ISO)

Developmental Disabilities (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

nephronophthisis (ISO)

spondyloepimetaphyseal dysplasia, Genevieve-type (ISO)

thoracic aortic aneurysm (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate biosynthetic process (IEA)

CMP-N-acetylneuraminate biosynthetic process (IEA)

glycosylation (IEA)

N-acetylneuraminate biosynthetic process (IEA)

N-acetylneuraminate metabolic process (IEA)

Cellular Component

cytosol (IEA,ISO)

Molecular Function

N-acylneuraminate-9-phosphate synthase activity (IEA)

transferase activity, transferring alkyl or aryl (other than methyl) groups (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (ISO)

french type sialuria pathway (ISO)

sialic acid storage disease pathway (ISO)

Tay-Sachs disease pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NANS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	41,375,294 - 41,409,330 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	41,377,671 - 41,411,713 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	69,146,016 - 69,172,355 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	97,267,088 - 97,293,385 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	97,267,088 - 97,293,385 (+)	Ensembl	panpan1.1		panPan2

NANS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	98,056,732 - 98,083,077 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	98,056,732 - 98,083,077 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	100,819,014 - 100,845,359 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	99,858,842 - 99,885,178 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	97,898,575 - 97,924,912	NCBI
Celera	9	71,333,236 - 71,359,642 (+)	NCBI		Celera
Cytogenetic Map	9	q22.33	NCBI
HuRef	9	70,419,093 - 70,445,498 (+)	NCBI		HuRef
CHM1_1	9	100,965,405 - 100,991,809 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	110,217,512 - 110,255,020 (+)	NCBI		T2T-CHM13v2.0

Nans
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	46,489,319 - 46,503,439 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	46,489,248 - 46,503,632 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	46,489,329 - 46,503,438 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	46,489,248 - 46,503,632 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	46,502,201 - 46,516,310 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	46,510,429 - 46,524,538 (+)	NCBI		MGSCv36	mm8
Celera	4	46,514,378 - 46,528,658 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	24.83	NCBI

Nans
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	65,575,970 - 65,593,164 (+)	NCBI		GRCr8
mRatBN7.2	5	60,780,441 - 60,797,583 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	60,780,392 - 60,814,950 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	62,751,649 - 62,768,600 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	64,571,024 - 64,587,971 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	64,540,435 - 64,557,380 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	62,109,352 - 62,126,492 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	62,109,328 - 62,126,494 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	66,637,340 - 66,654,051 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	63,072,673 - 63,090,183 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	63,069,334 - 63,090,249 (+)	NCBI
Celera	5	59,342,273 - 59,359,222 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Nans
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	27,424,674 - 27,448,952 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	27,424,648 - 27,449,058 (-)	NCBI	ChiLan1.0	ChiLan1.0

NANS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	55,286,290 - 55,310,904 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	55,243,854 - 55,350,194 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	53,719,899 - 53,744,431 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	56,398,348 - 56,422,901 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	56,398,269 - 56,425,087 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	54,894,201 - 54,918,744 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	54,924,876 - 54,949,416 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	55,621,300 - 55,645,840 (+)	NCBI		UU_Cfam_GSD_1.0

Nans
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	170,225,274 - 170,244,274 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	6,772,796 - 6,791,902 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	6,772,831 - 6,791,854 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NANS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	239,881,876 - 239,919,251 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	239,881,984 - 239,912,727 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	268,051,524 - 268,082,265 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NANS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	41,339,636 - 41,363,920 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	41,334,900 - 41,363,855 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	38,378,935 - 38,412,718 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nans
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	2,771,057 - 2,795,815 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	2,771,301 - 2,795,813 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008974061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000030997 ⟹ ENSPPAP00000008361

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	97,267,088 - 97,293,385 (+)	Ensembl

RefSeq Acc Id:

XM_008974061 ⟹ XP_008972309

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	41,375,294 - 41,409,330 (-)	NCBI
NHGRI_mPanPan1	9	41,377,671 - 41,411,713 (-)	NCBI
Mhudiblu_PPA_v0	9	69,146,016 - 69,172,355 (+)	NCBI
PanPan1.1	9	97,267,088 - 97,293,385 (+)	NCBI

Sequence:

show sequence

CCCGGCGACCGCGGGCTGACGTGGCGGGGCTGGCGTGTGGGTCTCGCAGCGCTGCTCACAGAAC
AGAGTAGAGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCGTTGGACTCCGAGCCGCT
GCAATGCCGCTGGAGCTGGAGCTGTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCA
TCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAAGCGCATGATCCGCAT
GGCCAAGGAGTGTGGGGCTGATTGTGCCAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAAT
CGGAAAGCCTTGGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACA
AACGACATCTGGAGTTCAGCCATGACCAGTACAGGGAGCTGCAGAGGTACGCCGAGGAGGTTGG
GATCTTCTTCACTGCCTCTGGCATGGATGAGATGGCAGTTGAATTCCTGCATGAACTGAATGTT
CCATTTTTCAAAGTTGGATCTGGAGACACTAATAATTTTCCTTATCTGGAAAAGACAGCCAAAA
AAGGTCGCCCAATGGTAATCTCCAGCGGGATGCAGTCAATGGACACCATGAAGCAAGTTTATCA
GATCGTGAAGCCCCTCAACCCCAACTTCTGCTTCTTGCAGTGTACCAGCGCATACCCGCTCCAG
CCTGAGGACGTCAACCTGCGGGTCATCTCGGAATATCAGAAGCTCTTTCCTGACATTCCCATAG
GGTATTCTGGGCATGAAACAGGCACAGCGATATCTGTGGCCGCAGTGGCTCTGGGGGCCAAGGT
GTTGGAACGTCACATAACTTTGGACAAGACCTGGAAGGGGAGTGACCACTCAGCCTCGCTGGAG
CCTGGAGAACTGGCCGAGCTGGTGCGGTCAGTGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAA
CCAAGCAGCTGCTGCCCTGTGAGATGGCCTGCAATGAGAAGCTGGGCAAGTCTGTGGTGGCCAA
AGTGAAAATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCGTGAAGGTGGGTGAGCCC
AAAGGCTATCCTCCTGAAGACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAAG
AGGATGACACCATCATGGAAGAATTGGTAGATAATCATGGCAAAAAAATCAAGTCTTAAAAATA
AAGTGCCATTCTCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008972309	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008361.1

RefSeq Acc Id:

XP_008972309 ⟸ XM_008974061

- UniProtKB:

A0A2R8ZUY3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNR
KALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFLHELNVP
FFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQP
EDVNLRVISEYQKLFPDIPIGYSGHETGTAISVAAVALGAKVLERHITLDKTWKGSDHSASLEP
GELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPK
GYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS

hide sequence

Ensembl Acc Id:

ENSPPAP00000008361 ⟸ ENSPPAT00000030997

Protein Domains

AFP-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027418	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000030997.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
	Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain	UniProtKB/TrEMBL
InterPro	AFP_Neu5c_C	UniProtKB/TrEMBL
	AFP_Neu5c_C_sf	UniProtKB/TrEMBL
	Aldolase_TIM	UniProtKB/TrEMBL
	Antifreeze_III	UniProtKB/TrEMBL
	Neu5Ac_N	UniProtKB/TrEMBL
	Nonulosonic_Acid_Synth	UniProtKB/TrEMBL
	SAF	UniProtKB/TrEMBL
KEGG Report	pps:100982112	UniProtKB/TrEMBL
NCBI Gene	NANS	ENTREZGENE
PANTHER	N-ACETYLNEURAMINATE SYNTHASE	UniProtKB/TrEMBL
	SIALIC ACID SYNTHASE	UniProtKB/TrEMBL
Pfam	NeuB	UniProtKB/TrEMBL
	SAF	UniProtKB/TrEMBL
PRINTS	ANTIFREEZIII	UniProtKB/TrEMBL
PROSITE	AFP_LIKE	UniProtKB/TrEMBL
SMART	SAF	UniProtKB/TrEMBL
Superfamily-SCOP	Aldolase	UniProtKB/TrEMBL
	SSF51269	UniProtKB/TrEMBL
UniProt	A0A2R8ZUY3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB