BPIFB1 (BPI fold containing family B member 1)

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Gene: BPIFB1 (BPI fold containing family B member 1) Pan paniscus

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Symbol:

BPIFB1

Name:

BPI fold containing family B member 1

RGD ID:

11974240

Description:

ENCODES a protein that exhibits lipid binding (inferred); INVOLVED IN innate immune response in mucosa (inferred); negative regulation of toll-like receptor 4 signaling pathway (inferred); ASSOCIATED WITH glutathione synthetase deficiency (ortholog); glutatione synthetase deficiency with 5-oxoprolinuria (ortholog); hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (ortholog); FOUND IN extracellular exosome (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BPI fold-containing family B member 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	38,978,220 - 39,002,814 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	38,971,318 - 38,995,913 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	29,572,667 - 29,599,158 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	30,688,567 - 30,715,127 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	30,688,567 - 30,715,127 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glutathione synthetase deficiency (ISO)

glutatione synthetase deficiency with 5-oxoprolinuria (ISO)

hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

innate immune response in mucosa (IEA)

negative regulation of toll-like receptor 4 signaling pathway (IEA)

Cellular Component

extracellular exosome (IEA)

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

lipid binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BPIFB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	38,978,220 - 39,002,814 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	38,971,318 - 38,995,913 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	29,572,667 - 29,599,158 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	30,688,567 - 30,715,127 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	30,688,567 - 30,715,127 (+)	Ensembl	panpan1.1		panPan2

BPIFB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	33,283,214 - 33,309,871 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	33,273,480 - 33,309,871 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	31,871,020 - 31,897,677 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	31,334,602 - 31,361,345 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	31,334,601 - 31,361,345	NCBI
Celera	20	28,624,683 - 28,651,429 (+)	NCBI		Celera
Cytogenetic Map	20	q11.21	NCBI
HuRef	20	28,658,391 - 28,685,136 (+)	NCBI		HuRef
CHM1_1	20	31,771,823 - 31,798,564 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	35,000,716 - 35,037,069 (+)	NCBI		T2T-CHM13v2.0

Bpifb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,032,738 - 154,062,263 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,032,738 - 154,062,289 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	154,190,818 - 154,220,343 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	154,190,818 - 154,220,369 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,016,554 - 154,046,079 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	153,882,259 - 153,911,784 (+)	NCBI		MGSCv36	mm8
MGSCv36	2	155,008,637 - 155,038,232 (+)	NCBI		MGSCv36	mm8
Celera	2	160,106,511 - 160,137,967 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	76.23	NCBI

Bpifb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	163,133,151 - 163,166,420 (+)	NCBI		GRCr8
mRatBN7.2	3	142,672,995 - 142,706,258 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	142,672,995 - 142,706,256 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	146,574,903 - 146,608,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	155,158,749 - 155,192,083 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	152,898,994 - 152,932,322 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	149,668,099 - 149,702,399 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	149,668,102 - 149,702,399 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	156,046,295 - 156,078,742 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	144,601,201 - 144,635,308 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	141,413,918 - 141,446,549 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Bpifb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	27,950,918 - 27,975,146 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	27,955,298 - 27,976,051 (-)	NCBI	ChiLan1.0	ChiLan1.0

BPIFB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,510,890 - 22,531,338 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,511,060 - 22,531,292 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	22,156,613 - 22,176,946 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	23,196,973 - 23,217,311 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	23,197,026 - 23,217,263 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	22,473,860 - 22,492,601 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,582,584 - 22,602,919 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,013,693 - 23,034,035 (+)	NCBI		UU_Cfam_GSD_1.0

Bpifb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	171,496,241 - 171,513,905 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936561	7,227,045 - 7,277,393 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BPIFB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	36,782,307 - 36,809,754 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	36,782,307 - 36,809,756 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	41,731,739 - 41,760,090 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BPIFB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	37,612,111 - 37,638,397 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	89,259,895 - 89,287,518 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bpifb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	5,951,203 - 5,972,212 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	5,951,202 - 5,972,212 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008967481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000035382 ⟹ ENSPPAP00000012716

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	30,688,567 - 30,715,127 (+)	Ensembl

RefSeq Acc Id:

XM_008967481 ⟹ XP_008965729

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	38,978,220 - 39,002,814 (+)	NCBI
NHGRI_mPanPan1	20	38,971,318 - 38,995,913 (+)	NCBI
Mhudiblu_PPA_v0	20	29,572,667 - 29,599,158 (+)	NCBI
PanPan1.1	20	30,688,567 - 30,715,127 (+)	NCBI

Sequence:

show sequence

GGTCTGAGGCCTCTGCCTAAAGACAAAGCCTGTGCTGGGGTGTGCAGGATATAAGGTTGGACTT
CCAGACCCACTGCCCAGGAGAGGAGAGGAGCGGGCCGAGGACTCCACCGTGCCCAGGTCTGGCA
TCCTGCACTTGCTGCTCTCTGACACCTGGGAAGATGGCCGGCCCGTGGACCTTCACCCTTCTCT
GTGGTTTGCTGGCAGCCGCCTTGATCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGG
CCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGCTGAAGGACCACAACGCCACCAGCATCCTG
CAGCAGCTGCCACTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGAGGCATCCCTGTGCTGGGCA
GCCTGGTGAACACCGTCCTGAAGCACATCATCTGGCTGAAGGTCATCACAGCTAACATCCTCCA
GCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGATCCCCCTGGACATGGTG
GCCGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACGACTGAGGCCCAAG
CCATCGTCCGCATGGACACCAGTGCAAGTGGCCCCACTCGCCTGGTCCTCAGTGACTGTGCCAC
CAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCTTAGCT
AAGCAGGTCATGAACCTGCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCCG
TGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTC
CCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAG
CTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCTG
CAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGT
GGTGAAAGCTGCAGTGGCTGCTGCGCTCCCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTG
CTTCCTGAGATTGCCCATCGGCTGAAGTCAAGCATCGGGCTGATCAATGAAAAGGCTGCAGATA
AGCTGGGGTCTACCCAGATCGTGAAGATCCTAACTCAGGACACTCCCGAGTTTTTTATAGACCA
AGGCCGTGCCAAGGTGGCCCAACTGATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGC
CCTTTGTTCACCCTGGGCATCGAAGCCAGCTCGGAAGCTCAGTTTTACACCAAAGGTGACCAAC
TTATACTCAACTTGAATAACATCAGCTCTGATCGGATCCAGCTGATGAACTCTGGGATTGGCTG
GTTCCAACCTGATGTTCTGAAAAACATCATCACTGAGATCATCCACTCCATCCTGCTGCCGAAC
CAGAATGGCAAATTAAGATCTGGGGTCCCAGTGTCATTGGTGAAGGCCTTGGGATTCGAGGCAG
CTGAGTCCTCACTGACCAAGGATGCCCTTGTGCTTACTCCAGCCTCCTTGTGGAAACCCACCTC
TCCTGTCTCCCAGTGAAGACTTGGATGGCAGCCATCAGGGAAGGCTGGGTCCCAGCTGGGAGTA
TGGGTGTGAGCTCCATAGACCATCCCTCTCTGCAATCAATAAACACTTGCCGGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_008965729	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000012716.1

RefSeq Acc Id:

XP_008965729 ⟸ XM_008967481

- Sequence:

show sequence

MAGPWTFTLLCGLLAAALIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMRE
KPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTI
VEFHMTTEAQAIVRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSL
PNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQ
GKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAALPPEEFMVLLDSVLPEIAHRLKSS
IGLINEKAADKLGSTQIVKILTQDTPEFFIDQGRAKVAQLIVLEVFPSSEALRPLFTLGIEASS
EAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPV
SLVKALGFEAAESSLTKDALVLTPASLWKPTSPVSQ

hide sequence

Ensembl Acc Id:

ENSPPAP00000012716 ⟸ ENSPPAT00000035382

Protein Domains

Lipid-binding serum glycoprotein N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029535	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035382.1	UniProtKB/TrEMBL
InterPro	Bactericidal_perm-incr_a/b_dom	UniProtKB/TrEMBL
	Bpifb1	UniProtKB/TrEMBL
	Lipid-bd_serum_glycop_C	UniProtKB/TrEMBL
	Lipid-bd_serum_glycop_N	UniProtKB/TrEMBL
KEGG Report	pps:100994251	UniProtKB/TrEMBL
NCBI Gene	BPIFB1	ENTREZGENE
PANTHER	BPI FOLD-CONTAINING FAMILY B MEMBER 1	UniProtKB/TrEMBL
	PTHR47395	UniProtKB/TrEMBL
Pfam	LBP_BPI_CETP	UniProtKB/TrEMBL
	LBP_BPI_CETP_C	UniProtKB/TrEMBL
PIRSF	PLUNC_long_form	UniProtKB/TrEMBL
SMART	BPI1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55394	UniProtKB/TrEMBL
UniProt	A0A2R9AAQ9_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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