KLHL4 (kelch like family member 4) - Rat Genome Database

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Gene: KLHL4 (kelch like family member 4) Pan paniscus
Analyze
Symbol: KLHL4
Name: kelch like family member 4
RGD ID: 11713632
Description: ASSOCIATED WITH autistic disorder (ortholog); autosomal hemophilia A (ortholog); factor VIII deficiency (ortholog); FOUND IN centriolar satellite (inferred); microtubule cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 4; kelch-like protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X86,985,286 - 87,136,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X86,988,893 - 87,139,812 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X76,575,811 - 76,726,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X86,678,423 - 86,828,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX86,678,164 - 86,829,346 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X86,985,286 - 87,136,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X86,988,893 - 87,139,812 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X76,575,811 - 76,726,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X86,678,423 - 86,828,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX86,678,164 - 86,829,346 (+)Ensemblpanpan1.1panPan2
KLHL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X87,517,802 - 87,670,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX87,517,409 - 87,670,050 (+)EnsemblGRCh38hg38GRCh38
GRCh37X86,772,805 - 86,925,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X86,659,465 - 86,811,706 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X86,578,961 - 86,730,741NCBI
CeleraX87,012,392 - 87,164,729 (+)NCBICelera
Cytogenetic MapXq21.31NCBI
HuRefX80,353,756 - 80,506,308 (+)NCBIHuRef
CHM1_1X86,665,377 - 86,817,732 (+)NCBICHM1_1
T2T-CHM13v2.0X85,944,797 - 86,097,065 (+)NCBIT2T-CHM13v2.0
Klhl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X113,384,030 - 113,470,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX113,384,030 - 113,470,526 (+)EnsemblGRCm39 Ensembl
GRCm38X114,474,333 - 114,561,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX114,474,333 - 114,560,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X111,588,129 - 111,674,307 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X110,591,464 - 110,677,642 (+)NCBIMGSCv36mm8
CeleraX101,283,043 - 101,355,844 (+)NCBICelera
Cytogenetic MapXE1NCBI
cM MapX49.47NCBI
Klhl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X83,626,047 - 83,916,328 (+)NCBIGRCr8
mRatBN7.2X79,429,193 - 79,719,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX79,622,113 - 79,719,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX81,310,098 - 81,407,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X84,708,360 - 84,805,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X82,296,515 - 82,393,646 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X86,125,929 - 86,229,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX86,126,157 - 86,229,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X86,066,906 - 86,171,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X103,218,938 - 103,317,748 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX80,890,575 - 80,987,712 (+)NCBICelera
Cytogenetic MapXq31NCBI
Klhl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555251,849,413 - 1,965,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555251,849,428 - 1,963,168 (+)NCBIChiLan1.0ChiLan1.0
KLHL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X67,949,674 - 68,111,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX67,949,034 - 68,109,486 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX58,721,143 - 58,882,528 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X69,291,043 - 69,450,378 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX69,291,089 - 69,448,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X66,926,923 - 67,088,348 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X68,569,225 - 68,730,643 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X68,163,017 - 68,324,360 (+)NCBIUU_Cfam_GSD_1.0
Klhl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X76,323,006 - 76,422,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649911,235,788 - 11,334,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649911,235,844 - 11,335,678 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX70,334,774 - 70,435,109 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X70,334,755 - 70,436,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X80,884,832 - 81,030,921 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X76,157,121 - 76,316,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX76,157,130 - 76,314,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660674,434,150 - 4,594,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624852493,040 - 629,663 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624852493,062 - 629,787 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000064572   ⟹   ENSPPAP00000041646
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX86,678,164 - 86,829,346 (+)Ensembl
RefSeq Acc Id: XM_003824444   ⟹   XP_003824492
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X86,985,286 - 87,136,205 (+)NCBI
NHGRI_mPanPan1X86,988,893 - 87,139,812 (+)NCBI
Mhudiblu_PPA_v0X76,575,812 - 76,726,676 (+)NCBI
PanPan1.1X86,678,423 - 86,828,738 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978156   ⟹   XP_008976404
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X86,985,322 - 87,135,697 (+)NCBI
NHGRI_mPanPan1X86,988,931 - 87,139,292 (+)NCBI
Mhudiblu_PPA_v0X76,575,811 - 76,726,687 (+)NCBI
PanPan1.1X86,678,423 - 86,828,301 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003824492 (Get FASTA)   NCBI Sequence Viewer  
  XP_008976404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000041646
  ENSPPAP00000041646.1
RefSeq Acc Id: XP_003824492   ⟸   XM_003824444
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CI62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976404   ⟸   XM_008978156
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSPPAP00000041646   ⟸   ENSPPAT00000064572
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043431 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000064572.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
KEGG Report pps:100973691 UniProtKB/TrEMBL
NCBI Gene KLHL4 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 4 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A2R9CI62 ENTREZGENE, UniProtKB/TrEMBL