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Gene: WFDC3 (WAP four-disulfide core domain 3) Pan paniscus

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Symbol:

WFDC3

Name:

WAP four-disulfide core domain 3

RGD ID:

11713514

Description:

ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN antibacterial humoral response (inferred); innate immune response (inferred); ASSOCIATED WITH adenosine deaminase deficiency (ortholog); focal epilepsy (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

WAP four-disulfide core domain protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,513,988 - 51,534,074 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,509,396 - 51,527,182 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	42,113,749 - 42,131,413 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	43,200,929 - 43,218,892 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	43,200,929 - 43,218,891 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenosine deaminase deficiency (ISO)

focal epilepsy (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial humoral response (IEA)

innate immune response (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

peptidase inhibitor activity (IEA)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

WFDC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,513,988 - 51,534,074 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,509,396 - 51,527,182 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	42,113,749 - 42,131,413 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	43,200,929 - 43,218,892 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	43,200,929 - 43,218,891 (-)	Ensembl	panpan1.1		panPan2

WFDC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,774,213 - 45,791,883 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	45,747,944 - 45,791,932 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	44,402,852 - 44,420,522 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,836,254 - 43,853,954 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	43,836,253 - 43,853,954	NCBI
Celera	20	41,113,350 - 41,131,041 (-)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	41,144,647 - 41,162,351 (-)	NCBI		HuRef
CHM1_1	20	44,305,556 - 44,323,245 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,510,745 - 47,528,411 (-)	NCBI		T2T-CHM13v2.0

Wfdc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,573,222 - 164,587,914 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,573,100 - 164,587,851 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,731,226 - 164,745,994 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,731,180 - 164,745,931 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	164,556,726 - 164,568,767 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,422,385 - 164,434,517 (-)	NCBI		MGSCv36	mm8
Celera	2	170,668,563 - 170,680,602 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	85.27	NCBI

Wfdc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,884,206 - 173,898,294 (-)	NCBI		GRCr8
mRatBN7.2	3	153,464,862 - 153,478,952 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,464,862 - 153,478,952 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	157,273,579 - 157,287,643 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,772,549 - 165,786,613 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	163,516,326 - 163,530,390 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	161,193,904 - 161,212,063 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,193,769 - 161,212,188 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,381,768 - 167,398,342 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,747,773 - 155,772,497 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	155,653,923 - 155,678,417 (-)	NCBI
Celera	3	152,073,171 - 152,087,062 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Wfdc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	11,502,918 - 11,512,143 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	11,501,044 - 11,512,109 (+)	NCBI	ChiLan1.0	ChiLan1.0

WFDC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	33,087,487 - 33,102,721 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	33,087,547 - 33,102,872 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,614,964 - 32,630,186 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,797,918 - 33,813,154 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,797,978 - 33,813,105 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	33,056,745 - 33,071,979 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	33,172,427 - 33,187,053 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,711,244 - 33,726,141 (-)	NCBI		UU_Cfam_GSD_1.0

Wfdc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,778,356 - 191,792,623 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936514	7,234,315 - 7,246,255 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WFDC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	17	47,976,078 - 47,994,744 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	53,622,109 - 53,640,803 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WFDC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,098,111 - 18,115,053 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,100,770 - 18,115,044 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,740,371 - 66,756,021 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wfdc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624790	8,789,875 - 8,800,843 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008951363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008951364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024926817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055104491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000012388 ⟹ ENSPPAP00000002604

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	43,200,929 - 43,218,891 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000012408 ⟹ ENSPPAP00000002614

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	43,201,144 - 43,217,127 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000012425 ⟹ ENSPPAP00000002616

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	20	43,201,144 - 43,217,127 (-)	Ensembl

RefSeq Acc Id:

XM_008951363 ⟹ XP_008949611

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	51,513,988 - 51,534,032 (-)	NCBI
NHGRI_mPanPan1	20	51,509,396 - 51,527,139 (-)	NCBI
Mhudiblu_PPA_v0	20	42,113,749 - 42,131,391 (-)	NCBI
PanPan1.1	20	43,200,929 - 43,218,891 (-)	NCBI

Sequence:

show sequence

CAGTCAAGGGATGTTTCCCGCTGGGCCAAGGCCTGGGGATGACTGCGGGCATCATCATGATGTT
AAGCTGCCTCTTTCTTCTGAAGGCACTTCTTGCTCTTGGGTCCCTGGAATCCTGGATAACTGCA
GGAGAACATGCAAAAGAGGGAGAATGCCCTCCCGATAAGAACCCATGCAAAGAGCTGTGCCAGG
GCGACGAATTGTGTCCGGCTGAACAGAAGTGCTGCACCACAGGCTGTGGTCGGATCTGCCGAGA
CATTCCTAAGGGGAGGAAAAGAGATTGCCCTAGGGTTATTCGGAAACAATCCTGTTTGAAAAGG
TGCATCACTGATGAGACATGTCCAGGTGTAAAGAAATGCTGCACGCTTGGCTGCAACAAGAGCT
GTGTAGTCCCAATCTCTAAACAGAAGCTGGCAGAGTTTGGTGGTGACTGTCCCGCTGACCCCCT
TCCGTGTGAGGAGCTGTGTGATGGGGATGCATCCTGTCCCCAGGGGCATAAATGCTGCAGCACC
GGCTGTGGCCGCACCTGCCTCGGAGACATTGAGGGAGGGCGGGGCGGTGATTGTCCAAAAGTTC
TGGTGGGCCTGTGCATTGTTGGCTGTGTGATGGATGAGAATTGTCAAGCTGGAGAAAAATGTTG
CAAGTCAGGCTGTGGCCGCTTCTGTGTCCCACCAGTACTGCCCCCAAAACTGACCATGAACCCC
AACTGGACTGTGAGGTCTGATTCCGAATTAGAGATCCCGGTGCCCTAGCTATGCCGATTTGTCT
GGAGCTTCTTTGGTAATTCTGGAAGCTTTTCCTGGCAGTCAAGAGAGGGTGACATCCTGGGGCT
TGTGACATTTTCAGGGGCACTCATGGCCCTCTCTGCGCTGCTTCTCCTCCTGCCGCTGACCAGA
GCATGGGAAATAGCCCTGGATTGGGCAGTGGGTGTGTGGTGCTTCTCTTTCCCAATAAAGGCTG
GTGCTGA

hide sequence

RefSeq Acc Id:

XM_024926817 ⟹ XP_024782585

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	51,513,988 - 51,534,021 (-)	NCBI
NHGRI_mPanPan1	20	51,509,396 - 51,527,129 (-)	NCBI
Mhudiblu_PPA_v0	20	42,113,749 - 42,131,413 (-)	NCBI
PanPan1.1	20	43,200,929 - 43,218,892 (-)	NCBI

Sequence:

show sequence

TCAGTCAAGGGATGTTTCCCGCTGGGCCAAGGCCTGGGGATGACTGCGGGGCACTTCTTGCTCT
TGGGTCCCTGGAATCCTGGATAACTGCAGGAGAACATGCAAAAGAGGGAGAATGCCCTCCCGAT
AAGAACCCATGCAAAGAGCTGTGCCAGGGCGACGAATTGTGTCCGGCTGAACAGAAGTGCTGCA
CCACAGGCTGTGGTCGGATCTGCCGAGACATTCCTAAGGGGAGGAAAAGAGATTGCCCTAGGGT
TATTCGGAAACAATCCTGTTTGAAAAGGTGCATCACTGATGAGACATGTCCAGGTGTAAAGAAA
TGCTGCACGCTTGGCTGCAACAAGAGCTGTGTAGTCCCAATCTCTAAACAGAAGCTGGCAGAGT
TTGGTGGTGACTGTCCCGCTGACCCCCTTCCGTGTGAGGAGCTGTGTGATGGGGATGCATCCTG
TCCCCAGGGGCATAAATGCTGCAGCACCGGCTGTGGCCGCACCTGCCTCGGAGACATTGAGGGA
GGGCGGGGCGGTGATTGTCCAAAAGTTCTGGTGGGCCTGTGCATTGTTGGCTGTGTGATGGATG
AGAATTGTCAAGCTGGAGAAAAATGTTGCAAGTCAGGCTGTGGCCGCTTCTGTGTCCCACCAGT
ACTGCCCCCAAAACTGACCATGAACCCCAACTGGACTGTGAGGTCTGATTCCGAATTAGAGATC
CCGGTGCCCTAGCTATGCCGATTTGTCTGGAGCTTCTTTGGTAATTCTGGAAGCTTTTCCTGGC
AGTCAAGAGAGGGTGACATCCTGGGGCTTGTGACATTTTCAGGGGCACTCATGGCCCTCTCTGC
GCTGCTTCTCCTCCTGCCGCTGACCAGAGCATGGGAAATAGCCCTGGATTGGGCAGTGGGTGTG
TGGTGCTTCTCTTTCCCAATAAAGGCTGGTGCTGA

hide sequence

RefSeq Acc Id:

XM_055104491 ⟹ XP_054960466

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	21	51,513,988 - 51,534,074 (-)	NCBI
NHGRI_mPanPan1	20	51,509,396 - 51,527,182 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_008949611	(Get FASTA)	NCBI Sequence Viewer
	XP_024782585	(Get FASTA)	NCBI Sequence Viewer
	XP_054960466	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000002604.1
	ENSPPAP00000002614.1
	ENSPPAP00000002616.1

RefSeq Acc Id:

XP_008949611 ⟸ XM_008951363

- Peptide Label:

isoform X3

- Sequence:

show sequence

MTAGIIMMLSCLFLLKALLALGSLESWITAGEHAKEGECPPDKNPCKELCQGDELCPAEQKCCT
TGCGRICRDIPKGRKRDCPRVIRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEF
GGDCPADPLPCEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKVLVGLCIVGCVMDE
NCQAGEKCCKSGCGRFCVPPVLPPKLTMNPNWTVRSDSELEIPVP

hide sequence

RefSeq Acc Id:

XP_024782585 ⟸ XM_024926817

- Peptide Label:

isoform X1

- Sequence:

show sequence

MFPAGPRPGDDCGALLALGSLESWITAGEHAKEGECPPDKNPCKELCQGDELCPAEQKCCTTGC
GRICRDIPKGRKRDCPRVIRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEFGGD
CPADPLPCEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKVLVGLCIVGCVMDENCQ
AGEKCCKSGCGRFCVPPVLPPKLTMNPNWTVRSDSELEIPVP

hide sequence

Ensembl Acc Id:

ENSPPAP00000002604 ⟸ ENSPPAT00000012388

Ensembl Acc Id:

ENSPPAP00000002614 ⟸ ENSPPAT00000012408

Ensembl Acc Id:

ENSPPAP00000002616 ⟸ ENSPPAT00000012425

RefSeq Acc Id:	XP_054960466 ⟸ XM_055104491
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZIU6 (UniProtKB/TrEMBL)

Protein Domains

WAP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000011377	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000012388.1	UniProtKB/TrEMBL
	ENSPPAT00000012408.1	UniProtKB/TrEMBL
	ENSPPAT00000012425.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.75.10	UniProtKB/TrEMBL
InterPro	Elafin-like_sf	UniProtKB/TrEMBL
	WAP_dom	UniProtKB/TrEMBL
	WAP_four-disulfide_core	UniProtKB/TrEMBL
NCBI Gene	WFDC3	ENTREZGENE
PANTHER	WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 3	UniProtKB/TrEMBL
	WHEY ACDIC PROTEIN WAP	UniProtKB/TrEMBL
Pfam	WAP	UniProtKB/TrEMBL
PRINTS	4DISULPHCORE	UniProtKB/TrEMBL
PROSITE	WAP	UniProtKB/TrEMBL
SMART	WAP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57256	UniProtKB/TrEMBL
UniProt	A0A2R8ZC28_PANPA	UniProtKB/TrEMBL
	A0A2R8ZIU6	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZIV8_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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