MINDY2 (MINDY lysine 48 deubiquitinase 2) - Rat Genome Database

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Gene: MINDY2 (MINDY lysine 48 deubiquitinase 2) Pan paniscus
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Symbol: MINDY2
Name: MINDY lysine 48 deubiquitinase 2
RGD ID: 11679118
Description: ENCODES a protein that exhibits cysteine-type carboxypeptidase activity (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin remodeling (inferred); protein K48-linked deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cell periphery (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FAM63B; family with sequence similarity 63 member B; ubiquitin carboxyl-terminal hydrolase MINDY-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21648,032,402 - 48,126,098 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,214,742 - 52,308,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,737,665 - 37,831,501 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11556,047,970 - 56,141,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1556,047,970 - 56,134,203 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MINDY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21648,032,402 - 48,126,098 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,214,742 - 52,308,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,737,665 - 37,831,501 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11556,047,970 - 56,141,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1556,047,970 - 56,134,203 (+)Ensemblpanpan1.1panPan2
MINDY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,771,302 - 58,861,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1558,771,192 - 58,861,900 (+)EnsemblGRCh38hg38GRCh38
GRCh371559,063,501 - 59,154,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,850,685 - 56,937,046 (+)NCBINCBI36Build 36hg18NCBI36
Celera1535,951,332 - 36,037,699 (+)NCBICelera
Cytogenetic Map15q21.3-q22.1NCBI
HuRef1535,885,953 - 35,972,658 (+)NCBIHuRef
CHM1_11559,181,343 - 59,267,684 (+)NCBICHM1_1
T2T-CHM13v2.01556,573,291 - 56,663,918 (+)NCBIT2T-CHM13v2.0
Mindy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,506,296 - 70,566,429 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,506,296 - 70,564,456 (-)EnsemblGRCm39 Ensembl
GRCm38970,599,014 - 70,657,856 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,599,014 - 70,657,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,446,821 - 70,504,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,403,759 - 70,456,322 (-)NCBIMGSCv36mm8
Celera967,815,959 - 67,874,302 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.53NCBI
Mindy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,149,127 - 80,210,011 (-)NCBIGRCr8
mRatBN7.2871,268,274 - 71,327,698 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,256,447 - 71,328,453 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0877,029,346 - 77,089,208 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,035,147 - 77,089,097 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,992,850 - 76,053,316 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,078,181 - 75,134,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,097,535 - 75,153,071 (-)NCBI
Celera870,401,551 - 70,460,881 (+)NCBICelera
Cytogenetic Map8q24NCBI
Mindy2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,753,892 - 15,808,205 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,753,892 - 15,808,205 (-)NCBIChiLan1.0ChiLan1.0
MINDY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,753,566 - 23,827,586 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,753,681 - 23,821,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,727,565 - 23,801,409 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,921,729 - 23,995,834 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,920,848 - 23,992,842 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,845,519 - 23,919,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,930,500 - 24,004,340 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03024,073,982 - 24,147,852 (+)NCBIUU_Cfam_GSD_1.0
Mindy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640102,089,417 - 102,171,572 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,937,254 - 20,012,777 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,937,550 - 20,015,138 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MINDY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,176,223 - 113,258,648 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,171,047 - 113,258,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,244,057 - 125,294,523 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MINDY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,662,351 - 24,747,383 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,664,998 - 24,746,225 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,573,624 - 116,655,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mindy2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,103,068 - 13,176,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,100,015 - 13,195,750 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000058064   ⟹   ENSPPAP00000035176
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1556,047,970 - 56,134,203 (+)Ensembl
RefSeq Acc Id: XM_003827898   ⟹   XP_003827946
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,425 - 48,126,098 (+)NCBI
NHGRI_mPanPan11552,214,759 - 52,308,610 (+)NCBI
Mhudiblu_PPA_v01537,738,405 - 37,831,501 (+)NCBI
PanPan1.11556,047,971 - 56,141,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008953221   ⟹   XP_008951469
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,424 - 48,126,098 (+)NCBI
NHGRI_mPanPan11552,214,742 - 52,308,610 (+)NCBI
Mhudiblu_PPA_v01537,738,405 - 37,828,027 (+)NCBI
PanPan1.11556,047,970 - 56,141,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008953222   ⟹   XP_008951470
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,425 - 48,126,098 (+)NCBI
NHGRI_mPanPan11552,214,756 - 52,308,610 (+)NCBI
Mhudiblu_PPA_v01537,737,665 - 37,831,501 (+)NCBI
PanPan1.11556,047,970 - 56,141,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055098272   ⟹   XP_054954247
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,425 - 48,126,098 (+)NCBI
NHGRI_mPanPan11552,214,750 - 52,308,610 (+)NCBI
RefSeq Acc Id: XM_063596679   ⟹   XP_063452749
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,420 - 48,126,098 (+)NCBI
RefSeq Acc Id: XM_063596680   ⟹   XP_063452750
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21648,032,402 - 48,126,098 (+)NCBI
RefSeq Acc Id: XP_008951469   ⟸   XM_008953221
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008951470   ⟸   XM_008953222
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003827946   ⟸   XM_003827898
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C0C7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000035176   ⟸   ENSPPAT00000058064
RefSeq Acc Id: XP_054954247   ⟸   XM_055098272
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063452750   ⟸   XM_063596680
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063452749   ⟸   XM_063596679
- Peptide Label: isoform X4
Protein Domains
MINDY deubiquitinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040407 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058064.1 UniProtKB/TrEMBL
InterPro MINDY UniProtKB/TrEMBL
  MINDY_domain UniProtKB/TrEMBL
KEGG Report pps:100981159 UniProtKB/TrEMBL
NCBI Gene FAM63B ENTREZGENE
PANTHER PTHR18063 UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-2 UniProtKB/TrEMBL
Pfam MINDY_DUB UniProtKB/TrEMBL
UniProt A0A2R9C0C7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 MINDY2  MINDY lysine 48 deubiquitinase 2  FAM63B  family with sequence similarity 63 member B  Symbol and/or name change 5135510 APPROVED