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Gene: STX10 (syntaxin 10) Pan paniscus

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Symbol:

STX10

Name:

syntaxin 10

RGD ID:

11671964

Description:

ENCODES a protein that exhibits SNAP receptor activity (inferred); syntaxin binding (inferred); INVOLVED IN early endosome to Golgi transport (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); FOUND IN cytosol (inferred); endomembrane system (inferred); Golgi apparatus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

syntaxin-10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	18,074,402 - 18,080,837 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	17,075,057 - 17,082,274 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,707,389 - 12,713,681 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	13,445,784 - 13,449,422 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,445,784 - 13,449,422 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 4 (ISO)

alpha-mannosidosis (ISO)

Charcot-Marie-Tooth disease dominant intermediate B (ISO)

episodic ataxia type 2 (ISO)

glutaric acidemia I (ISO)

Marshall-Smith syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

early endosome to Golgi transport (ISO)

Golgi vesicle transport (IEA)

intracellular protein transport (IEA)

membrane fusion (IEA)

protein transport (IEA)

regulation of protein localization (IEA)

retrograde transport, endosome to Golgi (IEA)

Cellular Component

cytosol (IEA)

endomembrane system (IEA)

Golgi apparatus (IEA)

Golgi membrane (IEA)

membrane (IEA)

organelle membrane (IEA)

perinuclear region of cytoplasm (IEA)

trans-Golgi network (IEA)

vesicle (IEA)

Molecular Function

protein binding (ISO)

SNAP receptor activity (IEA)

syntaxin binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

STX10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	18,074,402 - 18,080,837 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	17,075,057 - 17,082,274 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,707,389 - 12,713,681 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	13,445,784 - 13,449,422 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,445,784 - 13,449,422 (-)	Ensembl	panpan1.1		panPan2

STX10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	13,144,058 - 13,150,375 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	13,144,058 - 13,150,383 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	13,254,872 - 13,261,189 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	13,116,224 - 13,121,987 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	13,116,223 - 13,121,987	NCBI
Celera	19	13,145,623 - 13,151,385 (-)	NCBI		Celera
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,827,252 - 12,833,581 (-)	NCBI		HuRef
CHM1_1	19	13,255,825 - 13,262,142 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	13,269,272 - 13,275,588 (-)	NCBI		T2T-CHM13v2.0

STX10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,075,302 - 49,078,694 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	49,075,834 - 49,085,324 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	48,948,921 - 48,951,832 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	49,593,405 - 49,596,320 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	49,593,435 - 49,596,316 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	48,804,982 - 48,807,889 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	49,231,349 - 49,234,253 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	49,473,736 - 49,476,644 (+)	NCBI		UU_Cfam_GSD_1.0

Stx10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,179,244 - 208,186,434 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	2,172,067 - 2,175,366 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	2,168,272 - 2,175,803 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STX10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	65,914,127 - 65,917,070 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	65,914,132 - 65,917,075 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,214,676 - 66,217,583 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STX10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,827,745 - 11,833,916 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	7,948,333 - 7,956,311 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003814841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008967694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008967695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000061789 ⟹ ENSPPAP00000038880

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	13,445,784 - 13,449,422 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000061809 ⟹ ENSPPAP00000038900

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	13,446,136 - 13,449,226 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000061815 ⟹ ENSPPAP00000038906

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	13,446,583 - 13,449,226 (-)	Ensembl

RefSeq Acc Id:

XM_003814841 ⟹ XP_003814889

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	18,074,402 - 18,080,837 (-)	NCBI
NHGRI_mPanPan1	19	17,075,057 - 17,082,249 (-)	NCBI
Mhudiblu_PPA_v0	19	12,707,389 - 12,713,681 (-)	NCBI
PanPan1.1	19	13,445,784 - 13,449,422 (-)	NCBI

Sequence:

show sequence

AACCAAGATGGCTGCGGAGAGGGCGGAAGTGTCCGCACGTCGGGCCTCCGAGGCTTCTCTTTCT
CCCCTGGCGGTCCCGCTCTCGATGGTGGCGTGACGGGGGCGGGGGTGGCGACGCGTTCTCCTCG
GTTGGGAGGGAACCAGCCCGCGAACCCAGGCCGGGAGGGGGGTTCGGCCTGGGGGGGAAGGGAC
TGATATGTCTCTCGAAGACCCCTTTTTTGTAGTCCGAGGCGAGGTGCAGAAGGCGGTGAACACG
GCCCGCGGGCTGTACCAGCGCTGGTGCGAGCTCCTGCAGGAAAGCGCGGCGGTCGGACGCGAGG
AGCTGGACTGGACGACCAATGAGCTGCGGAATGGCCTGCGCAGCATCGAGTGGGACCTCGAGGA
CCTGGAAGAGACCATCGGTATAGTGGAAGCCAACCCAGGCAAGTTCAAGCTCCCAGCCGGGGAC
CTGCAGGAGAGAAAGGTGTTCGTGGAGCGGATGCGAGAGGCAGTCCAGGAAATGAAGGACCATA
TGGTCAGCCCAACAGCCGTAGCATTTTTGGAGAGGAATAACAGAGAGATACTCGCAGGCAAGCC
AGCTGCCCAGAAGTCACCCAGCGACCTGCTGGATGCCAGCGCAGTCTCGGCCACATCTCGCTAC
ATCGAGGAGCAGCAGGCCACACAGCAGCTGATCATGGATGAACAGGATCAACAGCTGGAGATGG
TGTCTGGGAGCATCCAGGTTCTGAAGCACATGTCCGGCCGCGTTGGGGAAGAGCTGGACGAGCA
GGGCATCATGCTGGATGCCTTCGCCCAAGAGATGGACCACACCCAGTCCCGCATGGACGGGGTC
CTCAGGAAGTTGGCCAAAGTATCCCACATGACGAGTGACCGCCGACAGTGGTGTGCCATCGCCG
TGCTAGTGGGGGTGCTTCTGCTCGTTCTCATCTTACTATTCTCTCTCTGACCCCAGCCCTCCCT
GGCAGGCTGGTCCCTTAAGCCTGGGGAGCCACCAAGCACTTTGGAGCTGGCCTCGCCCCCTAGG
AGGAGAGGGTCCCTCCTGGGTAGCTGGAGAGTAGAGGGTCCCGCCTGGGGAGCTGTCCCCATGG
CTCTCCCCTAGAGCCAGTGGGACCCTTCAGGACCCTGGGCTGGAACCACCACCACTGGTCCTGT
CTCAAGTGCACTTAGGGGGTGGTGGAGGCAGGGACACCTGAGACACACCTGTCTCCATTTCCAG
TTCCAGGACTCCAAAGCCATTTGCCCCTGTGCCTTATACACGTGCCAACCTGGAAATAAAATGT
CAGCCTTTTTTATACGTA

hide sequence

RefSeq Acc Id:

XM_008967694 ⟹ XP_008965942

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	18,074,402 - 18,080,705 (-)	NCBI
NHGRI_mPanPan1	19	17,075,057 - 17,081,355 (-)	NCBI
Mhudiblu_PPA_v0	19	12,707,389 - 12,713,681 (-)	NCBI
PanPan1.1	19	13,445,784 - 13,449,422 (-)	NCBI

Sequence:

show sequence

AACCAAGATGGCTGCGGAGAGGGCGGAAGTGTCCGCACGTCGGGCCTCCGAGGCTTCTCTTTCT
CCCCTGGCGGTCCCGCTCTCGATGGTGGCGTGACGGGGGCGGGGGTGGCGACGCGTTCTCCTCG
GTTGGGAGGGAACCAGCCCGCGAACCCAGGCCGGGAGGGGGGTTCGGCCTGGGGGGGAAGGGAC
TGATATGTCTCTCGAAGACCCCTTTTTTGTAGTCCGAGGCGAGGTGCAGAAGGCGGTGAACACG
GCCCGCGGGCTGTACCAGCGCTGGTGCGAGCTCCTGCAGGAAAGCGCGGCGGTCGGACGCGAGG
AGCTGGACTGGACGACCAATGAGCTGCGGAATGGCCTGCGCAGCATCGAGTGGGACCTCGAGGA
CCTGGAAGAGACCATCGGTATAGTGGAAGCCAACCCAGGCAAGTTCAAGCTCCCAGCCGGGGAC
CTGCAGGAGAGAAAGGTGTTCGTGGAGCGGATGCGAGAGGCAGTCCAGGAAATGAAGGACCATA
TGGTCAGCCCAACAGCCGTAGCATTTTTGGAGAGGAATAACAGAGAGATACTCGCAGGCAAGCC
AGCTGCCCAGAAGTCACCCAGCGACCTGCTGGATGCCAGCGCAGTCTCGGCCACATCTCGCTAC
ATCGAGGAGCAGCAGGCCACACAGCAGCTGATCATGGATGAACAGGATCAACAGCTGGAGATGG
TGTCTGGGAGCATCCAGGTTCTGAAGCACATGTCCGGCCGCGTTGGGGAAGAGCTGGACGAGCA
GGGCATCATGCTGGATGCCTTCGCCCAAGAGATGGACCACACCCAGTCCCGCATGGACGGGGTC
CTCAGGAAGTTGGCCAAAGTATCCCACATGACGAGTGTTCCAGGACTCCAAAGCCATTTGCCCC
TGTGCCTTATACACGTGCCAACCTGGAAATAAAATGTCAGCCTTTTTTATACGTA

hide sequence

RefSeq Acc Id:

XM_008967695 ⟹ XP_008965943

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	18,074,927 - 18,080,705 (-)	NCBI
NHGRI_mPanPan1	19	17,075,578 - 17,082,274 (-)	NCBI
Mhudiblu_PPA_v0	19	12,707,914 - 12,713,675 (-)	NCBI
PanPan1.1	19	13,446,309 - 13,449,422 (-)	NCBI

Sequence:

show sequence

AACCAAGATGGCTGCGGAGAGGGCGGAAGTGTCCGCACGTCGGGCCTCCGAGGCTTCTCTTTCT
CCCCTGGCGGTCCCGCTCTCGATGGTGGCGTGACGGGGGCGGGGGTGGCGACGCGTTCTCCTCG
GTTGGGAGGGAACCAGCCCGCGAACCCAGGCCGGGAGGGGGGTTCGGCCTGGGGGGGAAGGGAC
TGATATGTCTCTCGAAGACCCCTTTTTTGTAGTCCGAGGCGAGGTGCAGAAGGCGGTGAACACG
GCCCGCGGGCTGTACCAGCGCTGGTGCGAGCTCCTGCAGGAAAGCGCGGCGGTCGGACGCGAGG
AGCTGGACTGGACGACCAATGAGCTGCGGAATGGCCTGCGCAGCATCGAGTGGGACCTCGAGGA
CCTGGAAGAGACCATCGGTATAGTGGAAGCCAACCCAGGCAAGTTCAAGCTCCCAGCCGGGGAC
CTGCAGGAGAGAAAGGTGTTCGTGGAGCGGATGCGAGAGGCAGTCCAGGAAATGAAGGACCATA
TGGTCAGCCCAACAGCCGTAGCATTTTTGGAGAGGAATAACAGAGAGATACTCGCAGGCAAGCC
AGCTGCCCAGAAGTCACCCAGCGACCTGCTGGATGCCAGCGCAGTCTCGGCCACATCTCGCTAC
ATCGAGGAGCAGCAGGCCACACAGCAGCTGATCATGGATGAACAGGATCAACAGCTGGAGATGG
TGTCTGGGAGCATCCAGGTTCTGAAGCACATGTCCGGCCGCGTTGGGGAAGAGCTGGACGAGCA
GGCATGCTGGATGCCTTCGCCCAAGAGATGGACCACACCCAGTCCCGCATGGACGGGGTCCTCA
GGAAGTTGGCCAAAGTATCCCACATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003814889	(Get FASTA)	NCBI Sequence Viewer
	XP_008965942	(Get FASTA)	NCBI Sequence Viewer
	XP_008965943	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000038880
	ENSPPAP00000038880.1
	ENSPPAP00000038900.1
	ENSPPAP00000038906.1

RefSeq Acc Id:

XP_008965942 ⟸ XM_008967694

- Peptide Label:

isoform X2

- Sequence:

show sequence

MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDL
EETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNREILAGKPA
AQKSPSDLLDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEELDEQG
IMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSVPGLQSHLPLCLIHVPTWK

hide sequence

RefSeq Acc Id:	XP_003814889 ⟸ XM_003814841
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CA96 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDL EETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNREILAGKPA AQKSPSDLLDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEELDEQG IMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDRRQWCAIAVLVGVLLLVLILLFSL hide sequence

RefSeq Acc Id:

XP_008965943 ⟸ XM_008967695

- Peptide Label:

isoform X3

- Sequence:

show sequence

MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDL
EETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNREILAGKPA
AQKSPSDLLDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEELDEQA
CWMPSPKRWTTPSPAWTGSSGSWPKYPT

hide sequence

Ensembl Acc Id:

ENSPPAP00000038880 ⟸ ENSPPAT00000061789

Ensembl Acc Id:

ENSPPAP00000038906 ⟸ ENSPPAT00000061815

Ensembl Acc Id:

ENSPPAP00000038900 ⟸ ENSPPAT00000061809

Protein Domains

Syntaxin 6 N-terminal t-SNARE coiled-coil homology

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042146	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000061789.1	UniProtKB/TrEMBL
	ENSPPAT00000061809.1	UniProtKB/TrEMBL
	ENSPPAT00000061815.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.110	UniProtKB/TrEMBL
	1.20.58.90	UniProtKB/TrEMBL
InterPro	SNARE	UniProtKB/TrEMBL
	Syntaxin	UniProtKB/TrEMBL
	Syntaxin-6_N	UniProtKB/TrEMBL
	Syntaxin/epimorphin_CS	UniProtKB/TrEMBL
	T_SNARE_dom	UniProtKB/TrEMBL
KEGG Report	pps:100989116	UniProtKB/TrEMBL
NCBI Gene	STX10	ENTREZGENE
PANTHER	SYNTAXIN	UniProtKB/TrEMBL
	SYNTAXIN-10	UniProtKB/TrEMBL
Pfam	SNARE	UniProtKB/TrEMBL
	Syntaxin-6_N	UniProtKB/TrEMBL
PROSITE	SYNTAXIN	UniProtKB/TrEMBL
	T_SNARE	UniProtKB/TrEMBL
SMART	t_SNARE	UniProtKB/TrEMBL
Superfamily-SCOP	SNARE fusion complex	UniProtKB/TrEMBL
	SSF47661	UniProtKB/TrEMBL
UniProt	A0A2R9CA96	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CAB8_PANPA	UniProtKB/TrEMBL
	A0A2R9CAF2_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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