KLF18 (KLF transcription factor 18) - Rat Genome Database

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Gene: KLF18 (KLF transcription factor 18) Homo sapiens
Analyze
Symbol: KLF18
Name: KLF transcription factor 18
RGD ID: 10045909
HGNC Page HGNC:51793
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: KLF pseudogene; Kruppel like factor 18; Kruppel-like factor 18
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38144,137,821 - 44,141,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl144,137,821 - 44,141,631 (-)EnsemblGRCh38hg38GRCh38
GRCh37144,603,493 - 44,607,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p34.1NCBI
CHM1_1144,719,521 - 44,722,843 (-)NCBICHM1_1
T2T-CHM13v2.0144,008,117 - 44,012,630 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References
Additional References at PubMed
PMID:21873635   PMID:24244731  


Genomics

Comparative Map Data
KLF18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38144,137,821 - 44,141,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl144,137,821 - 44,141,631 (-)EnsemblGRCh38hg38GRCh38
GRCh37144,603,493 - 44,607,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p34.1NCBI
CHM1_1144,719,521 - 44,722,843 (-)NCBICHM1_1
T2T-CHM13v2.0144,008,117 - 44,012,630 (-)NCBIT2T-CHM13v2.0
Zfp352
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39490,107,057 - 90,113,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl490,107,057 - 90,113,939 (+)EnsemblGRCm39 Ensembl
GRCm38490,218,820 - 90,225,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl490,218,820 - 90,225,702 (+)EnsemblGRCm38mm10GRCm38
MGSCv37489,885,511 - 89,892,378 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36489,710,838 - 89,717,705 (+)NCBIMGSCv36mm8
Celera488,668,918 - 88,675,785 (+)NCBICelera
Cytogenetic Map4C5NCBI
cM Map442.31NCBI
Zfp353
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85110,190,863 - 110,192,455 (-)NCBIGRCr8
mRatBN7.25105,075,075 - 105,076,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5105,075,075 - 105,076,667 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05108,746,039 - 108,748,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5108,746,080 - 108,747,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05112,701,506 - 112,704,061 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45110,020,670 - 110,022,262 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15110,025,895 - 110,027,488 (-)NCBI
Celera5103,775,605 - 103,778,162 (-)NCBICelera
Cytogenetic Map5q32NCBI
KLF18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21182,668,564 - 182,672,030 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11181,809,983 - 181,813,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,439,446 - 43,442,911 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1144,810,023 - 44,812,395 (-)NCBIpanpan1.1PanPan1.1panPan2
KLF18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,126,631 - 16,133,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,248,622 - 16,255,711 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01516,281,338 - 16,288,435 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11516,080,218 - 16,087,305 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,148,476 - 16,155,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,221,690 - 16,228,787 (+)NCBIUU_Cfam_GSD_1.0
KLF18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603328,271,805 - 28,275,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in KLF18
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3-34.1(chr1:38222737-45636176)x3 copy number gain See cases [RCV000051803] Chr1:38222737..45636176 [GRCh38]
Chr1:38688409..46101848 [GRCh37]
Chr1:38460996..45874435 [NCBI36]
Chr1:1p34.3-34.1		 pathogenic
GRCh38/hg38 1p34.1(chr1:43896056-44867736)x3 copy number gain See cases [RCV000142581] Chr1:43896056..44867736 [GRCh38]
Chr1:44361728..45333408 [GRCh37]
Chr1:44134315..45105995 [NCBI36]
Chr1:1p34.1		 uncertain significance
GRCh38/hg38 1p34.2-34.1(chr1:40462415-44668040)x1 copy number loss See cases [RCV000053837] Chr1:40462415..44668040 [GRCh38]
Chr1:40928087..45133712 [GRCh37]
Chr1:40700674..44906299 [NCBI36]
Chr1:1p34.2-34.1		 pathogenic
GRCh38/hg38 1p34.2-34.1(chr1:40693289-44514104)x1 copy number loss See cases [RCV000050706] Chr1:40693289..44514104 [GRCh38]
Chr1:41158961..44979776 [GRCh37]
Chr1:40931548..44752363 [NCBI36]
Chr1:1p34.2-34.1		 pathogenic
NM_001358438.1(KLF18):c.1599A>G (p.Thr533=) single nucleotide variant not provided [RCV003406445] Chr1:44140033 [GRCh38]
Chr1:44605705 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.1419G>A (p.Gly473=) single nucleotide variant not provided [RCV003406446] Chr1:44140213 [GRCh38]
Chr1:44605885 [GRCh37]
Chr1:1p34.1		 likely benign
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
NM_001358438.1(KLF18):c.1290T>C (p.Cys430=) single nucleotide variant not provided [RCV003406447] Chr1:44140342 [GRCh38]
Chr1:44606014 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.2424C>T (p.Tyr808=) single nucleotide variant not provided [RCV003406443] Chr1:44139208 [GRCh38]
Chr1:44604880 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.2046C>T (p.Tyr682=) single nucleotide variant not provided [RCV003406444] Chr1:44139586 [GRCh38]
Chr1:44605258 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.2397G>A (p.Thr799=) single nucleotide variant not provided [RCV003993055] Chr1:44139235 [GRCh38]
Chr1:44604907 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.2385G>A (p.Gly795=) single nucleotide variant not provided [RCV003993056] Chr1:44139247 [GRCh38]
Chr1:44604919 [GRCh37]
Chr1:1p34.1		 likely benign
NM_001358438.1(KLF18):c.1557A>G (p.Thr519=) single nucleotide variant not provided [RCV003885158] Chr1:44140075 [GRCh38]
Chr1:44605747 [GRCh37]
Chr1:1p34.1		 likely benign

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
102 180 234 156 399 113 158 19 109 9 189 426 459 307 44 473 123 10

Sequence


Ensembl Acc Id: ENST00000634670   ⟹   ENSP00000489024
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl144,137,821 - 44,141,631 (-)Ensembl
RefSeq Acc Id: NM_001358438   ⟹   NP_001345367
RefSeq Status: INFERRED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38144,137,821 - 44,141,631 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047443665   ⟹   XP_047299621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0144,008,117 - 44,012,630 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001345367 (Get FASTA)   NCBI Sequence Viewer  
  XP_047299621 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0U1RQI7 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000489024
  ENSP00000489024.1
RefSeq Acc Id: NP_001345367   ⟸   NM_001358438
- UniProtKB: A0A0U1RQI7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000489024   ⟸   ENST00000634670
RefSeq Acc Id: XP_047299621   ⟸   XM_047443665
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0U1RQI7-F1-model_v2 AlphaFold A0A0U1RQI7 1-1052 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:51793 AgrOrtholog
COSMIC KLF18 COSMIC
Ensembl Genes ENSG00000283039 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000634670 ENTREZGENE
  ENST00000634670.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.150.10.10 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000283039 GTEx
HGNC ID HGNC:51793 ENTREZGENE
Human Proteome Map KLF18 Human Proteome Map
InterPro Serralysin-like_metalloprot_C UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
NCBI Gene KLF18 ENTREZGENE
OMIM 621009 OMIM
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  KRUPPEL-LIKE FACTOR 18 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA166181550 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A0U1RQI7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-11 KLF18  KLF transcription factor 18  KLF18  Kruppel like factor 18  Symbol and/or name change 19259463 PROVISIONAL
2016-06-07 KLF18  Kruppel like factor 18    Kruppel-like factor 18  Symbol and/or name change 5135510 APPROVED