CVCL_A8RU - Rat Genome Database

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Cell Line : CVCL_A8RU (N1380) Homo sapiens

Symbol: CVCL_A8RU
Name: N1380
RGD ID: 150518355
Cell Line Type: cancer cell line
Origin: Population: African; Shangaan; Karyotypic information: Has lost chromosome Y (from parent cell line); Transformant: Hepatitis B virus (HBV)(NCBI-Taxonomy; 10407); Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Gender: Male
Characteristics: Virology: Not susceptible to infection by porcine sapelovirus Transduced with Cas9 and then with the GeCKO v2 whole genome CRISPR/Cas9 library of guide RNAs. The resulting cells were then infected with porcine sapelovirus (PSV) (PubMed=32496007).
Genomic Alteration: Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg112Gly (c.334C>G) (p.Pro126Arg, c.377C>G); ClinVar=VCV000233484; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 12363; TSC2; Simple; p.Asn1651Ser (c.4952A>G); ClinVar=VCV000049335; Zygosity=Homozygous (from parent cell line); Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9; Transfected with: UniProtKB; P33967; B.cereus Bsr; Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR)
Derived From Cell Lines: CVCL_0485 (PLC/PRF/5)
Disease(s): adult hepatocellular carcinoma (DOID:0070328) [NCI:C7956,ORDO:210159]

References
Additional References at PubMed
PMID:32496007   PMID:33952773  


Additional Information

Database Acc Id Source(s)
cancercelllines CVCL_A8RU CELLOSAURUS
Cellosaurus CVCL_A8RU CELLOSAURUS
NCIt C7956 CELLOSAURUS
Orphanet 210159 CELLOSAURUS
Wikidata Q108821004 CELLOSAURUS