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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354000
Species: Homo sapiens
RGD Object: Gene
Symbol: P2RY12
Name: purinergic receptor P2Y12
Acc ID: CHEBI:90841
Term: cangrelor
Definition: A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.
Chemical ID: MESH:C117446
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2RY12affects response to substanceEXP 6480464CTDP2RY12 gene polymorphism affects the susceptibility to cangrelorPMID:20126830
P2RY12decreases activityEXP 6480464CTDcangrelor results in decreased activity of P2RY12 proteinPMID:22273509
P2RY12multiple interactionsEXP 6480464CTD[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate; [cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK proteinPMID:12606772
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