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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736918
Species: Homo sapiens
RGD Object: Gene
Symbol: SHOX2
Name: SHOX homeobox 2
Acc ID: CHEBI:85993
Term: palbociclib
Definition: A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.
Chemical ID: MESH:C500026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHOX2multiple interactionsEXP 6480464CTDpalbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]PMID:22094256
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