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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735555
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCS1
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCS1multiple interactionsISOHmgcs1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNAPMID:29852127
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