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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317785
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c65increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP2C65 mRNAPMID:20936131
Cyp2c65multiple interactionsEXP 6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2C65 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CYP2C65 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of CYP2C65 mRNA; PPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of CYP2C65 mRNA]PMID:20936131 PMID:36331819
Cyp2c65multiple interactionsISOCYP2C9 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]PMID:21964418
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