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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345114
Species: Homo sapiens
RGD Object: Gene
Symbol: DUOX1
Name: dual oxidase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DUOX1increases expressionEXP 6480464CTDParaquat results in increased expression of DUOX1 mRNAPMID:25177032 PMID:34097952
DUOX1multiple interactionsEXP 6480464CTDkaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA]PMID:25177032
DUOX1increases expressionISODuox1 (Mus musculus)6480464CTDParaquat results in increased expression of DUOX1 mRNAPMID:21688324
DUOX1multiple interactionsISODuox1 (Mus musculus)6480464CTDAPOD protein affects the reaction [Paraquat results in increased expression of DUOX1 mRNA]PMID:21688324
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