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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325364
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir497
Name: microRNA 497
Acc ID: CHEBI:3215
Term: bupivacaine
Definition: A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Chemical ID: MESH:D002045
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir497increases expressionISOMIR497 (Homo sapiens)6480464CTDBupivacaine results in increased expression of MIR497 mRNAPMID:35410500
Mir497multiple interactionsISOMIR497 (Homo sapiens)6480464CTDMIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]; MIR497 mRNA inhibits the reaction [SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; MIR497 mRNA promotes the reaction [Bupivacaine results in decreased expression of NLRX1 mRNA]; NLRX1 protein affects the reaction [MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; SNHG12 inhibits the reaction [Bupivacaine results in increased expression of MIR497 mRNA]PMID:35410500
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