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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna2d2
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna2d2affects methylationISOCACNA2D2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CACNA2D2 intronPMID:30157460
Cacna2d2decreases methylationISOCACNA2D2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CACNA2D2 promoterPMID:27901495
Cacna2d2increases methylationISOCACNA2D2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CACNA2D2 exonPMID:27901495
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