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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68656
Species: Mus musculus
RGD Object: Gene
Symbol: Dclk1
Name: doublecortin-like kinase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of DCLK1 mRNA

PMID:18343893, PMID:26377647
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DCLK1 mRNA

PMID:19933214
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of DCLK1 mRNA

PMID:15328365, PMID:23994337
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLK1 mRNA

PMID:17942748
increases expressionISORGD:686556480464CTDTetrachlorodibenzodioxin results in increased expression of DCLK1 mRNA

PMID:19619570, PMID:20106945
multiple interactionsISORGD:686556480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA, [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNA

PMID:19619570, PMID:26159488
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.