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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp4
Name: insulin-like growth factor binding protein 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp4affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of IGFBP4 mRNAPMID:22298810 PMID:34747641
Igfbp4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of IGFBP4 mRNAPMID:23639626
Igfbp4multiple interactionsEXP 6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP4 protein]; IGFBP4 mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of AKT1 protein]; Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IGFBP4 proteinPMID:23639626
Igfbp4affects expressionISOIgfbp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of IGFBP4 mRNAPMID:21570461
Igfbp4affects expressionISOIGFBP4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of IGFBP4 mRNAPMID:20106945
Igfbp4decreases expressionISOIgfbp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IGFBP4 mRNAPMID:19465110
Igfbp4decreases expressionISOIGFBP4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IGFBP4 mRNAPMID:19901195
Igfbp4increases expressionISOIgfbp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IGFBP4 mRNAPMID:21496263
Igfbp4increases expressionISOIGFBP4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of IGFBP4 mRNAPMID:21496263 PMID:21632981
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