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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320224
Species: Homo sapiens
RGD Object: Gene
Symbol: CBR3
Name: carbonyl reductase 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CBR3affects expressionISOCbr3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CBR3 mRNAPMID:18343893 PMID:20702594 PMID:26377647
CBR3increases expressionISOCbr3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CBR3 mRNAPMID:15800033 PMID:16611356 PMID:18691609 PMID:18796159 PMID:19933214 PMID:20819909 PMID:23864506 PMID:26290441
CBR3multiple interactionsISOCbr3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CBR3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CBR3 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CBR3 gene]PMID:16214954 PMID:20819909 PMID:25975270
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