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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732031
Species: Homo sapiens
RGD Object: Gene
Symbol: MVK
Name: mevalonate kinase
Acc ID: CHEBI:16057
Term: prenyl diphosphate
Definition: A prenol phosphate that is a phosphoantigen comprising the O-pyrophosphate of prenol.
Chemical ID: MESH:C043060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MVKdecreases activityEXP 6480464CTD3,3-dimethylallyl pyrophosphate results in decreased activity of MVK proteinPMID:9392419
MVKmultiple interactionsEXP 6480464CTD3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]PMID:9392419
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