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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of IFNG mRNAPMID:19382104
Ifngmultiple interactionsEXP 6480464CTD[Diethylhexyl Phthalate affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of SCARB1 mRNA; [Diethylhexyl Phthalate affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of SCARB2 mRNA; [Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IFNG protein; Diethylhexyl Phthalate affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD36 mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of MARCO mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of MMP9 mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of SCARB2 mRNA]; Diethylhexyl Phthalate promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL2 mRNA]; Diethylhexyl Phthalate promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]PMID:19428943 PMID:29718165
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