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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDAspirin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]PMID:19164858
Ifngincreases expressionISOIfng (Rattus norvegicus)6480464CTDAspirin results in increased expression of IFNG proteinPMID:19788892
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDfucoidan promotes the reaction [Aspirin results in increased expression of IFNG protein]PMID:19788892
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDAspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IFNG protein]PMID:15379866
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