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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737448
Species: Mus musculus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catincreases activityISOCat (Rattus norvegicus)6480464CTDalpha-Tocopherol results in increased activity of CAT proteinPMID:18547560 PMID:19941068
Catincreases expressionISOCat (Rattus norvegicus)6480464CTDalpha-Tocopherol results in increased expression of CAT proteinPMID:22732938
Catincreases expressionISOCAT (Homo sapiens)6480464CTDalpha-Tocopherol results in increased expression of CAT mRNA; alpha-Tocopherol results in increased expression of CAT proteinPMID:19083475
Catmultiple interactionsISOCat (Rattus norvegicus)6480464CTD[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; [Curcumin co-treated with alpha-Tocopherol] inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Sodium Selenite co-treated with alpha-Tocopherol] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [Copper Sulfate results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Camptothecin results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein]PMID:16979807 PMID:19464315 PMID:20194575 PMID:21322096 PMID:25233897 PMID:25304969 PMID:27823922 PMID:30057697 PMID:31022331 PMID:9306888
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]PMID:26365763 PMID:36058301
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