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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737312
Species: Homo sapiens
RGD Object: Gene
Symbol: AGER
Name: advanced glycosylation end-product specific receptor
Acc ID: CHEBI:76162
Term: indoprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Chemical ID: MESH:D007216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGERmultiple interactionsEXP 6480464CTDIndoprofen inhibits the reaction [HMGB1 protein results in increased expression of AGER mRNA]; Indoprofen inhibits the reaction [HMGB1 protein results in increased expression of and affects the localization of AGER protein]PMID:34755645
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