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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737133
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTA2
Name: glutathione S-transferase alpha 2
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTA2increases expressionISOGsta2 (Rattus norvegicus)6480464CTD2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA; 2-tert-butylhydroquinone results in increased expression of GSTA2 proteinPMID:12242683 PMID:15155840 PMID:15870285 PMID:7587946
GSTA2multiple interactionsISOGsta2 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2]; 2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]PMID:12242683 PMID:15155840 PMID:15319326 PMID:15357004 PMID:15870285 PMID:7587946
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