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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737065
Species: Mus musculus
RGD Object: Gene
Symbol: Mgll
Name: monoglyceride lipase
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgllaffects abundanceEXP 6480464CTDMGLL protein affects the abundance of glyceryl 2-arachidonatePMID:30301768
Mgllincreases abundanceEXP 6480464CTDMGLL gene mutant form results in increased abundance of glyceryl 2-arachidonatePMID:25030704
Mgllincreases degradationEXP 6480464CTDMGLL protein results in increased degradation of glyceryl 2-arachidonatePMID:25030704
Mgllincreases hydrolysisEXP 6480464CTDMGLL protein results in increased hydrolysis of glyceryl 2-arachidonatePMID:18096503 PMID:26209559
Mgllmultiple interactionsEXP 6480464CTD[FMR1 gene mutant form results in increased activity of MGLL] which results in increased degradation of glyceryl 2-arachidonate; [JZL 184 results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate; [MJN110 results in decreased activity of MGLL protein] which results in decreased hydrolysis of and results in increased abundance of glyceryl 2-arachidonatePMID:20393458 PMID:25030704 PMID:26209559 PMID:26791602
Mgllincreases hydrolysisISOMgll (Rattus norvegicus)6480464CTDMGLL protein results in increased hydrolysis of glyceryl 2-arachidonatePMID:21507991
Mgllmultiple interactionsISOMgll (Rattus norvegicus)6480464CTD[Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate; JZL 184 inhibits the reaction [MGLL protein results in increased hydrolysis of glyceryl 2-arachidonate]PMID:21507991 PMID:23761300 PMID:26642910
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