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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736908
Species: Mus musculus
RGD Object: Gene
Symbol: Spr
Name: sepiapterin reductase
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sprdecreases expressionEXP 6480464CTDtitanium dioxide results in decreased expression of SPR mRNAPMID:23557971
Sprdecreases methylationEXP 6480464CTDtitanium dioxide results in decreased methylation of SPR gene; titanium dioxide results in decreased methylation of SPR promoterPMID:35295148
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