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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736897
Species: Homo sapiens
RGD Object: Gene
Symbol: DCTN4
Name: dynactin subunit 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DCTN4affects expressionISODctn4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of DCTN4 mRNAPMID:21570461
DCTN4multiple interactionsISODctn4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCTN4 mRNA; DCTN4 promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:17942748 PMID:23997114
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