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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736793
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLCdecreases expressionISOGclc (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of GCLC mRNAPMID:32955216 PMID:37019170
GCLCmultiple interactionsISOGclc (Mus musculus)6480464CTDHydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA]PMID:32955216
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