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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736793
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLCaffects methylationEXP 6480464CTDhydroquinone affects the methylation of GCLC promoterPMID:23940045
GCLCincreases expressionEXP 6480464CTDhydroquinone results in increased expression of GCLC mRNAPMID:23940045 PMID:32334435
GCLCmultiple interactionsEXP 6480464CTD[hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine; [hydroquinone affects the methylation of GCLC promoter] which results in increased abundance of 5-hydroxymethylcytosine; Resveratrol promotes the reaction [hydroquinone results in increased expression of GCLC mRNA]; TET1 protein affects the reaction [hydroquinone results in increased expression of GCLC mRNA]PMID:23940045 PMID:32334435
GCLCincreases expressionISOGclc (Mus musculus)6480464CTDhydroquinone results in increased expression of GCLC mRNA; hydroquinone results in increased expression of GCLC proteinPMID:23290930 PMID:30547568
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