GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lgals3 | decreases response to substance | ISO | LGALS3 (Homo sapiens) | 6480464 | CTD | LGALS3 results in decreased susceptibility to N-acetylsphingosine | PMID:21821001 | Lgals3 | increases expression | ISO | LGALS3 (Homo sapiens) | 6480464 | CTD | N-acetylsphingosine results in increased expression of LGALS3 protein | PMID:21821001 | Lgals3 | multiple interactions | ISO | LGALS3 (Homo sapiens) | 6480464 | CTD | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] | PMID:21821001 | | ||||||||||||||||||||||
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