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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736305
Species: Mus musculus
RGD Object: Gene
Symbol: Lgals3
Name: lectin, galactose binding, soluble 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lgals3increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of LGALS3 mRNAPMID:22228805 PMID:23735875
Lgals3affects methylationISOLGALS3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of LGALS3 promoterPMID:27901495
Lgals3increases expressionISOLGALS3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of LGALS3 mRNA; Benzo(a)pyrene results in increased expression of LGALS3 proteinPMID:16269432 PMID:18495319 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291
Lgals3increases methylationISOLGALS3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of LGALS3 5' UTRPMID:27901495
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