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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736172
Species: Homo sapiens
RGD Object: Gene
Symbol: SHBG
Name: sex hormone binding globulin
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHBGaffects bindingEXP 6480464CTDDibutyl Phthalate binds to SHBG proteinPMID:25349334
SHBGmultiple interactionsEXP 6480464CTD[Phthalic Acids results in increased abundance of Dibutyl Phthalate] which results in increased expression of and results in increased secretion of SHBG proteinPMID:28637469
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