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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736172
Species: Homo sapiens
RGD Object: Gene
Symbol: SHBG
Name: sex hormone binding globulin
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHBGdecreases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in decreased expression of SHBG mRNAPMID:38568856
SHBGincreases expressionISOShbg (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of SHBG mRNAPMID:16380112
SHBGmultiple interactionsISOShbg (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]PMID:9171990
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