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GENE - TERM ANNOTATION REPORT

RGD ID: 736120
Species: Homo sapiens
RGD Object: Gene
Symbol: VAMP1
Name: vesicle associated membrane protein 1
Acc ID: DOID:607
Term: paraplegia
Definition: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Definition Source(s): MESH:D010264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:11774073 PMID:22958904 PMID:26467025 PMID:28492532
VAMP1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:28253535 PMID:28492532
VAMP1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:28492532
VAMP1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:26467025 PMID:28492532
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:25741868 PMID:28168212 PMID:28492532
VAMP1 IAGP (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:25741868 PMID:28492532
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:28253535 PMID:28492532 PMID:30293248
VAMP1 IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:17576681 PMID:28492532 PMID:9536098
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:26467025 PMID:28253535 PMID:28492532 PMID:33631708
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:17576681 PMID:22958904 PMID:26467025 PMID:28492532 PMID:9536098
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:28492532 PMID:35499206
VAMP1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Spastic paraplegiaPMID:25741868 PMID:26467025 PMID:28492532
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