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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735827
Species: Homo sapiens
RGD Object: Gene
Symbol: GOT1
Name: glutamic-oxaloacetic transaminase 1
Acc ID: CHEBI:78540
Term: apremilast
Definition: A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
Chemical ID: MESH:C505730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GOT1multiple interactionsISOGot1 (Rattus norvegicus)6480464CTDapremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein]PMID:27785949
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