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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735806
Species: Homo sapiens
RGD Object: Gene
Symbol: FGF9
Name: fibroblast growth factor 9
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FGF9increases expressionEXP 152177688RGD2,3,7,8-tetrachlorodibenzodioxine increases expression of FGF9 mRNA and protein in lung epithelial cell 
FGF9affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of FGF9 mRNAPMID:30203000 PMID:36370075
FGF9increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FGF9 mRNAPMID:19358281 PMID:20106945 PMID:21632981
FGF9multiple interactionsEXP 6480464CTDN-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF9 mRNA]PMID:30203000
FGF9affects expressionISOFgf9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FGF9 mRNAPMID:26377647
FGF9multiple interactionsISOFgf9 (Rattus norvegicus)6480464CTD[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of FGF9 mRNAPMID:21602191
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