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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735648
Species: Homo sapiens
RGD Object: Gene
Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
Acc ID: CHEBI:63637
Term: vemurafenib
Definition: A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.
Chemical ID: MESH:C551177
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NRASaffects response to substanceEXP 6480464CTDNRAS protein mutant form affects the susceptibility to vemurafenibPMID:27222248
NRASmultiple interactionsEXP 6480464CTD[NRAS protein mutant form affects the susceptibility to Vemurafenib] which results in increased expression of TNFRSF10B protein; [NRAS protein mutant form affects the susceptibility to Vemurafenib] which results in increased phosphorylation of MAPK1 protein; [NRAS protein mutant form affects the susceptibility to Vemurafenib] which results in increased phosphorylation of MAPK3 proteinPMID:27222248
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