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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735512
Species: Homo sapiens
RGD Object: Gene
Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:61080
Term: romidepsin
Definition: A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.
Chemical ID: MESH:C087123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MCL1increases expressionEXP 6480464CTDromidepsin results in increased expression of MCL1 proteinPMID:27634878
MCL1multiple interactionsEXP 6480464CTD[romidepsin co-treated with mirdametinib co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with mirdametinib] results in increased expression of MCL1 protein; [romidepsin co-treated with MK 2206] results in increased expression of MCL1 protein; romidepsin inhibits the reaction [Bortezomib results in increased expression of MCL1 protein]PMID:18223231 PMID:27634878
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