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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735435
Species: Homo sapiens
RGD Object: Gene
Symbol: SULT1A1
Name: sulfotransferase family 1A member 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SULT1A1affects response to substanceEXP 6480464CTDSULT1A1 protein affects the susceptibility to afimoxifenePMID:16517757
SULT1A1affects sulfationEXP 6480464CTDSULT1A1 gene polymorphism affects the sulfation of afimoxifenePMID:16517757
SULT1A1increases metabolic processingEXP 6480464CTDSULT1A1 protein results in increased metabolism of afimoxifenePMID:30120701
SULT1A1increases response to substanceEXP 6480464CTDSULT1A1 protein results in increased susceptibility to afimoxifenePMID:16517757
SULT1A1increases sulfationEXP 6480464CTDSULT1A1 protein results in increased sulfation of afimoxifenePMID:16517757
SULT1A1multiple interactionsEXP 6480464CTD[SULT1A1 3' UTR SNP affects the activity of SULT1A1 protein] which affects the metabolism of afimoxifene; [SULT1A1 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifenePMID:30120701
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