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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735373
Species: Homo sapiens
RGD Object: Gene
Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMPR2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of BMPR2 intron; Benzo(a)pyrene affects the methylation of BMPR2 promoterPMID:27901495 PMID:30157460
BMPR2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of BMPR2 mRNAPMID:20064835 PMID:20106945 PMID:21632981
BMPR2multiple interactionsISOBmpr2 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BMPR2 mRNAPMID:27858113
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