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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733941
Species: Homo sapiens
RGD Object: Gene
Symbol: NAE1
Name: NEDD8 activating enzyme E1 subunit 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NAE1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NAE1 mRNAPMID:29275510
NAE1increases expressionEXP 6480464CTDbisphenol A results in increased expression of NAE1 proteinPMID:34186270 PMID:37567409
NAE1increases expressionISONae1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of NAE1 mRNAPMID:25181051 PMID:34947998
NAE1increases methylationISONae1 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of NAE1 genePMID:28505145
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