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GENE - TERM ANNOTATION REPORT

RGD ID: 733900
Species: Mus musculus
RGD Object: Gene
Symbol: Rad50
Name: RAD50 double strand break repair protein
Acc ID: DOID:5683
Term: hereditary breast ovarian cancer syndrome
Definition: A syndrome characterized by the higher than normal tendency associated with BRCA1 and BRCA2 to develop breast and ovarian cancers in genetically related families. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Hereditary_breast%E2%80%93ovarian_cancer_syndrome "DO" "DO", http://www.cancer.gov/cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional/page1 "DO" "DO", https://www.jax.org/education-and-learning/clinical-and-continuing-education/cancer-resources/hereditary-breast-and-ovarian-cancer-syndrome-factsheet "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK1247/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 2 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 4 | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:27913932 PMID:28492532 PMID:28550065 PMID:28873162 PMID:29338689 PMID:29566657 PMID:29726012 PMID:29752822 PMID:29785153 PMID:29891727 PMID:29961768 PMID:30306255 PMID:30441849 PMID:30755392 PMID:31159747 PMID:31589614 PMID:31666926 PMID:31742824 PMID:32019284 PMID:32295079 PMID:32566746 PMID:32832836 PMID:32984025 PMID:33378670 PMID:33471991 PMID:34567246 PMID:35884469
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 2 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 4 | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:28492532 PMID:28550065 PMID:28873162 PMID:29338689 PMID:29566657 PMID:29726012 PMID:29752822 PMID:29785153 PMID:29891727 PMID:29961768 PMID:30306255 PMID:30441849 PMID:30755392 PMID:31159747 PMID:31666926 PMID:31742824 PMID:32019284 PMID:32295079 PMID:32566746 PMID:32832836 PMID:32984025 PMID:33378670 PMID:33471991
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 2 | ClinVar Annotator: match by term: Hereditary breast and ovarian cancer syndrome | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24763289 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26467025 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:27913932 PMID:28492532 PMID:28550065 PMID:28873162 PMID:29338689 PMID:29566657 PMID:29726012 PMID:29752822 PMID:29785153 PMID:29891727 PMID:29961768 PMID:30306255 PMID:30441849 PMID:30755392 PMID:31159747 PMID:31589614 PMID:31666926 PMID:31742824 PMID:32019284 PMID:32295079 PMID:32566746 PMID:32832836 PMID:32854451 PMID:32984025 PMID:33378670 PMID:33471991 PMID:33563768 PMID:34567246 PMID:35884469 PMID:37262986
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 2 | ClinVar Annotator: match by term: Hereditary breast and ovarian cancer | ClinVar Annotator: match by term: Hereditary breast and ovarian cancer syndrome | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16199547 PMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24763289 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26467025 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:27913932 PMID:28492532 PMID:28550065 PMID:28873162 PMID:29338689 PMID:29566657 PMID:29726012 PMID:29752822 PMID:29785153 PMID:29891727 PMID:29961768 PMID:30306255 PMID:30441849 PMID:30755392 PMID:31159747 PMID:31589614 PMID:31666926 PMID:31742824 PMID:32019284 PMID:32295079 PMID:32566746 PMID:32832836 PMID:32854451 PMID:32984025 PMID:33378670 PMID:33471991 PMID:33563768 PMID:34567246 PMID:35534218 PMID:35884469 PMID:36135357 PMID:37262986
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 2 | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24240112 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:28492532 PMID:28550065 PMID:29338689 PMID:29752822 PMID:30306255 PMID:30441849 PMID:31159747 PMID:31666926 PMID:32295079 PMID:32566746
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Breast-ovarian cancer, familial, susceptibility to, 1 | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:18281469 PMID:19409520 PMID:23555315 PMID:24240112 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:28492532 PMID:28550065 PMID:29338689 PMID:29752822 PMID:30306255 PMID:30441849 PMID:31159747 PMID:31666926 PMID:32295079 PMID:32566746
Rad50 ISORAD50 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Breast and/or ovarian cancer | ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromePMID:16385572 PMID:18281469 PMID:19409520 PMID:23555315 PMID:24240112 PMID:24894818 PMID:25151137 PMID:25452441 PMID:25741868 PMID:26689913 PMID:26757417 PMID:26787654 PMID:26824983 PMID:27732944 PMID:27783279 PMID:28492532 PMID:28550065 PMID:28873162 PMID:29338689 PMID:29566657 PMID:29752822 PMID:29961768 PMID:30306255 PMID:30441849 PMID:30755392 PMID:31159747 PMID:31666926 PMID:31742824 PMID:32019284 PMID:32295079 PMID:32566746 PMID:32832836 PMID:32984025 PMID:33378670 PMID:33471991
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